Comparing the metabolic response (oxygenuptake and ventilation) and symptom perception (borgscores for dyspnoea and fatigue) between neuromuscular electrical stimulation with low-frequency and high-frequency.
ID
Source
Brief title
Condition
- Respiratory disorders NEC
Synonym
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
Metabolic response:
- Oxygen uptake (VO2)
- Ventilation (VE)
Secondary outcome
Symptom perception:
- Borgscores for dyspnoea before and after the electrical stimulation
- Borgscores for fatigue of the leg muscles before and after the electrical
stimulation
Background summary
Patients with chronic obstructive pulmonary disease (COPD) still suffer from
disabling dyspnoea, fatigue and exercise intolerance in daily life despite
optimal drug treatment. Unfortunately, not every COPD patient is able to
complete conventional training methods, due to exercise-induced dyspnoea.
Transcutaneous neuromuscular electrical stimulation (NMES) is a relative new
treatment modality, which has been shown to have positive effects on skeletal
muscle function, exercise tolerance and disease-specific health status in
patients with COPD.
Study objective
Comparing the metabolic response (oxygenuptake and ventilation) and symptom
perception (borgscores for dyspnoea and fatigue) between neuromuscular
electrical stimulation with low-frequency and high-frequency.
Study design
A prospective cross-over intervention study design.
Intervention
Neuromuscular electrical stimulation
Study burden and risks
The current research group believes that the nature and possible extent of the
burden and risks possibly related to the present protocol are nihil and
acceptable. Neuromuscular electrical stimulation had been used in previous
studies (Neder et al, Thorax 2002; Bourjeily-Habr, Thorax 2002) and in daily
routine without any adverse events.
The mobile oxycon had been used in previous studies in healthy subjects and
patients with moderate to very severe COPD during exercise tests (for example:
Probst et al, Chest 2004) and during extensive rehabolitation sessions (Probste
et al, CERJ 2006) without any adverse events.
Universiteitssingel 50
6229 ER, Maastricht
Nederland
Universiteitssingel 50
6229 ER, Maastricht
Nederland
Listed location countries
Age
Inclusion criteria
Chronic Obstructive Pulmonary Disease (COPD)
High rate of dyspnoea (MRC 4/5)
Normal or underweigth (BMI<25 kg/m2)
Exclusion criteria
Long-term oxygen therapy
Pacemaker or Internal Cardiac Defibrillator
Metal implants in hip, leg and/or knee
Neurological and/or locomotorical problems
Design
Recruitment
Medical products/devices used
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
In other registers
| Register | ID |
|---|---|
| CCMO | NL25877.068.08 |
| OMON | NL-OMON28216 |