Evaluation whether there is 99mTc-IL2 uptake in vulnerable carotid plaques of patients on long-term treatment with statins.
ID
Source
Brief title
Condition
- Arteriosclerosis, stenosis, vascular insufficiency and necrosis
Synonym
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
Uptake value of radio-active IL-2
Secondary outcome
Comparison between SPECT and IP-guardian camera
Background summary
A coratid stenosis will only cause complaints in case of embolisation of plauqe
material. Not the stenosis severity but the vulnerability is an important
factor in embolisation. With radio-active IL-2 vulnerability can be detected.
At this moment it is unclear if this methode is usefull in patients on longterm
statin therapy.
Study objective
Evaluation whether there is 99mTc-IL2 uptake in vulnerable carotid plaques of
patients on long-term treatment with statins.
Study design
mono-center observatonal pilot study
Study burden and risks
The only extra burden is the IL-2 scan. One hour after injection the patients
will be scanned during a 45 minute period. The total duration will approximate
2 hours.
Hanzeplein 1
9713 GZ Groningen
NL
Hanzeplein 1
9713 GZ Groningen
NL
Listed location countries
Age
Inclusion criteria
Scheduled carotis endartiectomy
More than 3 months on statin therapy
Exclusion criteria
pregnancy
Design
Recruitment
Medical products/devices used
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| EudraCT | EUCTR2008-005289-29-NL |
| CCMO | NL23562.042.08 |