What is the clinical course of m. quadriceps muscle function in COPD?
ID
Source
Brief title
Condition
- Respiratory disorders NEC
Synonym
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
Maximal Voluntary Contraction of the m. quadriceps femoris
Secondary outcome
Nvt.
Background summary
Quadriceps strength is on average reduced by 30% in patients with chronic
obstructive pulmonary disease (COPD) when compared to healthy age matched
individuals. This is believed to be a consequence of progressive inactivity
and/or systemic inflammatory burden. Recent data demonstrates that reduced
quadriceps strength gives greater prognostic information than certain variables
used in previous models to predict COPD mortality.
Study objective
What is the clinical course of m. quadriceps muscle function in COPD?
Study design
This is a 1 year longitudinal study with patients with moderate to very severe
COPD.
Study burden and risks
Satisfactory measurements by an experienced examiner should be obtainable
within 15 minutes. There are no serious risks associated with the MVC testing
procedure. Mild, transient muscle cramps or discomfort from prolonged
positoning as discribed are occasionally reported.
Hornerheide 1
6085 NM Horn
Nederland
Hornerheide 1
6085 NM Horn
Nederland
Listed location countries
Age
Inclusion criteria
COPD (GOLD II-IV)
Exclusion criteria
Patients will not have the MVC recorded if they report any known confounding musculoskeletal or neuromuscular pathology affecting the right leg. This will include:
1) Severe osteoarthritis of either the right hip or knee joint which causes pain when positioned or performing the manoeuvre;
2) Compressive spinal pathology affecting the lumbar nerve roots;
3) Polyneuropathy or mononeuropathy affecting the femoral nerve. Patients with diabetes will general NOT be considered to fall into this category;
4) Co-existent or progressive motor neuron, neuromuscular junction or primary muscle disease;
5) Previous stroke (thrombo-embolic or haemorrhagic) affecting the right side;
6) Critical peripheral vascular disease affecting proximal leg blood flow (aorto-iliac disease).
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| CCMO | NL22616.040.08 |