To demonstrate the likelihood of the motor causes of drooling in PD: reduced swallowing frequency (akinesia), open mouth and mouth breathing (rigidity), reduced swallowing capacity (hypokinesia) and stooped posture.
ID
Source
Brief title
Condition
- Movement disorders (incl parkinsonism)
Synonym
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
Statistically significant differences between the two groups concerning
swallowing frequency, swallowing capacity and breathing pattern.
Secondary outcome
Not applicable
Background summary
Loss of saliva (drooling) is a frequent complaint in patients with Parkinson's
disease (PD), reported by 30% or more. Current treatments are aimed at
diminishing saliva production, mostly by injections with botulinum toxin in the
saliva glands. Increasing evidence suggests that drooling is not caused by
hypersecretion, but is due to motor disorders, typical for PD-patients.
Possibly these causes could be treated using behavioral techniques.
Study objective
To demonstrate the likelihood of the motor causes of drooling in PD: reduced
swallowing frequency (akinesia), open mouth and mouth breathing (rigidity),
reduced swallowing capacity (hypokinesia) and stooped posture.
Study design
Observational (enriched cohort study). PD-patients with daily drooling and
PD-patients without any complaints about drooling are recruted after regular
assessent at the movement disorders clinic and asked to fill in a questionnaire
to assess severity. All patients are observed with the same measures: the
swallowing frequency is measured with surface EMG electrodes on the floor of
the mouth and the larynx and the airflow near the nose is measured, while the
patient is relaxing in a chair during 45 minutes. Subsequently, breating
capacity is measured with a spirometer and salivaproduction with a known swab
technique, during 2 minutes.
Study burden and risks
Burden for the patient: self-administered questionniare of 7 items and watching
tv for 45 minutes without a pause and without drinking or eating.
Risks: none.
Postbus 9101
6500 HB Nijmegen
Nederland
Postbus 9101
6500 HB Nijmegen
Nederland
Listed location countries
Age
Inclusion criteria
Confirmed diagnosis of Parkinson's disease or parkinsonism
Complaints of moderate or severe drooling OR no complaint about saliva control at all.
Stable regime of anti-parkinson medication.
Ability to sit in a chair for min. 75 minutes.
Exclusion criteria
Mild or unclear complaints about drooling
Unable to follow instructions
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| CCMO | NL19569.091.07 |