No registrations found.
ID
Source
Health condition
Obsessive-compulsive disorder
Panic disorder
Intensive CBT
nonresponders
obsessieve compulsieve stoornis
Paniekstoornis
intensieve cognitieve gedragstherapie
Sponsors and support
Intervention
Outcome measures
Primary outcome
OCD or panic disorder symptoms
Secondary outcome
Depressive symptoms, general functionig and quality of life.
Background summary
Patients, who are non-responding on CBT for panic disorder of obsessive-compulsive disorder will receive an intensive 8-day CBT, followed by 4 weekly booster sessions. The study usus a multiple baseline design. Pirmary symptoms are assessed in 4 phases.
The patients are recuited in The Netherlands
Study design
The study consists of 4 phases, the baseline phase, the intervention phase, the post-intervention phase and the follow-up.
During the total study duration of 19 weeks patients have weekly assessments of their main symptoms.
Before and after every phase the secondary outcome measures are assessed (4 assessments in total).
Intervention
In the present study, intensive CBT treatment will be delivered in 8 days (in two weeks). CBT will take place in different locations, at home, in public transportation, etc. After the intensive phase, patients will receive 4 boostersessions of 90 minutes during 4 weeks and an evaluation session.
There is a baseline phase, which is the control for the active fase.
Inclusion criteria
A primary diagnosis of panic disorder or obsessive-compulsive disorder according to the DSM IV(assessed with the MINI, Sheehan et al 1998; Overbeek et al.,1999).
Age between 18-70.
Patients have had an adequate CBT treatment. An adequate CBT treatment is defined as CBT with exposure and response prevention with most weekly sessions for at least a period of 12 weeks for panic disorder and 20 weeks for OCD.
Patients still have significant symptoms and did not experience a significant change in symptoms. Significant symptoms are defined as a score of at least 11 on the Panic Disorder Severity Scale (PDSS; Shear et al., 1992) or a score of at least 10 when the diagnosis is panic disorder without agoraphobia, and a score of at least 4 on the Clinical Global Impression (CGI; Guy, 1976). Significant symptoms for OCD are defined as a score of at least 16 on the Yale-Brown Obsessive Compulsive Scale (Y-BOCS; Goodman, 1989) or a score of at least 10 when the diagnosis is primary obsessions, and a score of at least 4 on the Clinical Global Impression (CGI; Guy, 1976).
Concurrent use of antidepressants is allowed, doses have to be kept constant during the study. PD patients have to be on a constant dose 2 months before the study, OCD patient have to be on a constant dose 3 months before the study.
Concurrent use of benzodiazepines is allowed, when kept on a constant dose and taken at fixed times and not exceed the equivalence of 30 mg oxazepam.
Exclusion criteria
Severe, unstable mental disorder like depressive disorder or risk of suicide, psychotic disorder or bipolar disorder (assessed with the MINI);
Comorbid diagnosis of hoarding;
Cognitive malfunctions
Mental retardation;
Patient is not able to focus on treatment for 2 weeks because of social problems;
Inability to read, write and speak in the Dutch language;
Patient will not be able to taper off drug or alcohol use before treatment.
Design
Recruitment
Followed up by the following (possibly more current) registration
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| NTR-new | NL4738 |
| NTR-old | NTR4992 |
| CCMO | NL49574.072.14 |
| OMON | NL-OMON42267 |