No registrations found.
ID
Source
Brief title
Health condition
- contrast induced nephropathy
- acute kidney injury
- contrastnefropathie
- acute nierinfufficiëntie
Sponsors and support
Intervention
Outcome measures
Primary outcome
Mean increase in serum creatinine 2-4 days after contrast administration.
Secondary outcome
1. Contrast induced nephropathy defined as an increase in serum creatinine > 25% or 44 umol/liter 2-4 days after contrast administration;
2. Chronic loss of renal function after 2 months defined by the definition of contrast induced nephropathy;
3. Contrast induced need for dialysis;
4. Heartfailure due to volume suppletion with an indication for diuretics;
5. Chronic loss of renal function 1 year after contrast administration definined as an increase in serum creatinine > 25% of > 44 µmol/l,
Background summary
N/A
Study objective
A brief sodium bicarbonate infusion of 250 ml 1 our prior to contrast administration is non-inferior to pre and posthydration with a 1000 ml sodium chloride for and after the procedure.
Study design
1. Before contrast adminisatrion;
2. 2-4 days after contrast administration;
3. 2 months after contrast administration;
4. 1 year after contrast administration.
Intervention
1. 250 mL Sodium Bicarbonate 1 hour prior to contrast administration vs.
2. 1000 ml Sodium Chloride prior and after contrast administration.
Judith Kooiman
Leiden University Medical Center, Albinusdreef 2, Postzone C4-70
Leiden 2333 ZA
The Netherlands
+31 (0)71-526.20.85
j.kooiman@lumc.nl
Judith Kooiman
Leiden University Medical Center, Albinusdreef 2, Postzone C4-70
Leiden 2333 ZA
The Netherlands
+31 (0)71-526.20.85
j.kooiman@lumc.nl
Inclusion criteria
1. eGFR < 60ml/min/1.73m2;
2. In and outpatients.
Exclusion criteria
1. Age < 18 years;
2. Patients with a known allergy for contrast media;
3. Pregnancy;
4. Previous contrast adminisatrions in the last 7 days;
5. No informed consent.
Design
Recruitment
Followed up by the following (possibly more current) registration
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| NTR-new | NL2574 |
| NTR-old | NTR2699 |
| CCMO | NL33992.058.10 |
| ISRCTN | ISRCTN wordt niet meer aangevraagd. |
| OMON | NL-OMON37953 |