No registrations found.
ID
Source
Brief title
Health condition
acute childhood asthma
Sponsors and support
Intervention
Outcome measures
Primary outcome
Improvement in asthma score 1 hour after intervention.
Secondary outcome
1. Need for hospital admission;
2. Duration of hosptial admission;
3. Asthma score at 2,6,12 and 24 hours after intervention;
4. Heart rate, respiratory rate and oxygen saturation;
5. Need for additional oxygen;
6. Number of bronchodilators;
7. Doctor’s visit or readmission and use of rescue bronchodilator aerosol therapy following 72 hours after discharge from EMD;
8. Cost-consequence analysis.
Background summary
N/A
Study objective
We hypothesize that rhDNase can liquefy sputum in acute asthma resulting in less airways obstruction, reduced work of breathing, and diminished ventilation-perfusion mismatch, thereby improving symptoms, reducing the number of patients who need to be admitted, and shorten the duration of admission.
Study design
N/A
Intervention
One dose of 5 mg DNase OR one dose of 5 mg placebo in addition to standard care.
P.O. Box 2060
R. Boogaard
Rotterdam 3000 CB
The Netherlands
+31 (0)10 4636683
r.boogaard@erasmusmc.nl
P.O. Box 2060
R. Boogaard
Rotterdam 3000 CB
The Netherlands
+31 (0)10 4636683
r.boogaard@erasmusmc.nl
Inclusion criteria
Children, aged 2-18 years, with acute asthma who require at least two doses of bronchodilators at the emergency department.
Exclusion criteria
1. Dyspnoea due to other causes than asthma;
2. Patients with a concurrent chronic pulmonary disease, such as CF, BPD;
3. Patients with a symptomatic cardial or neuromuscular disease.
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| NTR-new | NL203 |
| NTR-old | NTR240 |
| Other | : N/A |
| ISRCTN | ISRCTN81874766 |