No registrations found.
ID
Source
Health condition
esophageal cancer
Sponsors and support
Intervention
Outcome measures
Primary outcome
Quality of the MRI images as defined by robustness (i.e. that the protocol can successfully be applied in various patients) and geometrical accuracy. Those parameters are derived using image analysis. MR images are obtained before, during and/or after chemoradiotherapy.
Secondary outcome
N/A
Background summary
This study is aimed at optimizing a MR sequences for esophageal cancer imaging before, during and after chemoradiation. We will focus on diffusion-weighted imaging and dynamic contrast enhanced imaging. The obtained protocol will be used in future to verify if MRI can be used for treatment response monitoring of neo-adjuvant radiotherapy.
Study objective
A robust and geometrically correct MRI protocol can be developed that enables functional MR imaging before, during and after chemoradiation of esophageal cancer.
Study design
Before, during and after radiotherapy.
Intervention
None (patients undergo an MRI scan with contrast agent).
A.L.H.M.W. Lier, van
Utrecht 3584 CX
The Netherlands
+31 (0)88 7558800
a.l.h.m.w.vanlier@umcutrecht.nl
A.L.H.M.W. Lier, van
Utrecht 3584 CX
The Netherlands
+31 (0)88 7558800
a.l.h.m.w.vanlier@umcutrecht.nl
Inclusion criteria
1. Patients with pathologically proven esophageal cancer referred to the department of Radiotherapy for
radiotherapy;
2. >18 years;
3. Written informed consent.
Exclusion criteria
1. Glomerular Filtration Rate (GFR) of <45 mL/min/1.73m2, unless the patient has risk factors for contrast nefropathy according to the UMCU protocol ‘Preventie contrastreactie en contrast nefropathie, Versie 2 februari
2012’. In patients with risk factors a GFR of 60 mL/min/1.73m2 will be required;
2. Known Gadovist allergy;
3. Patients who meet exclusion criteria for MRI following the protocol of the radiology department of the UMC Utrecht.
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| NTR-new | NL3682 |
| NTR-old | NTR3852 |
| Other | METC UMC Utrecht / CCMO Toetsingonline : 12/537 / NL42338.041.12; |
| ISRCTN | ISRCTN wordt niet meer aangevraagd. |