No registrations found.
ID
Source
Brief title
Health condition
Barrett Esophagus, Barrett neoplasia
Sponsors and support
Intervention
Outcome measures
Primary outcome
To evaluate feasibility of the workflow of using a re al-time, image-based CAD system in the endoscopy suite.
Secondary outcome
To assess the preliminary diagnostic accuracy of the CAD system for real-time detection of Barrett neoplasia.
Background summary
Barrett’s Esophagus (BE) is a known precursor for esophageal adenocarcinoma (EAC). BE patients undergo regular endoscopic
surveillance by general endoscopists to detect EAC at an early stage. However, endoscopic detection of early neoplasia is difficult
and early lesions are therefore often missed. Primarily, this is due to its subtle appearance.
The ability of modern-day computers to automatically recognize informative patterns in data sets can potentially improve endoscopic
detection of early neoplastic BE. Recently, a CAD system has been developed by our group that can automatically detect and
localize early neoplastic Barrett lesions on endoscopic WLE images with high accuracy.
The aim of this pilot study is to interrogate the feasibility of the endoscopic workflow, using this image-based CAD system real-time in the
endoscopy suite.
Study objective
The use of an-image based CAD system is feasible and enables endoscopic detection of Barrett neoplasia
Study design
Outcome measures apply to the endoscopic procedure. No further time point apply to this study.
Inclusion criteria
- Age>18 years;
- Patients with NDBE referred for endoscopic surveillance, or patients referred for endoscopic work-up of HGD or
EAC likely to require endoscopic resection (EMR or ESD);
- Signed informed consent.
Exclusion criteria
- Prior history of surgical or endoscopic treatment for oesophageal neoplasia;
- Presence of erosive esophagitis (Los Angeles classification ≥A);
- Inability to undergo EMR/ESD and/or obtain biopsies (e.g. due to anticoagulation, coagulation disorders,
varices).
Design
Recruitment
IPD sharing statement
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| NTR-new | NL7544 |
| Other | MEC Amsterdam University Medical Centers, Location AMC : METC 2018_334 |