No registrations found.
ID
Source
Health condition
Larynx cancer
Radiotherapy
Prediction
PET scan
Sponsors and support
Intervention
Outcome measures
Primary outcome
Overall survival.
Secondary outcome
1. Local control;
2. Regional control;
3. Distant metastases.
Background summary
Accurate prediction of survival and local control can help in the selection of patients for optimized treatment. Therefore it is valuable to develop an accurate, data-driven model to predict overall survival and local control in larynx cancer patients in order to individualize treatment. CTPET-imaging might have a predictive value for response in larynx cancer. In this study CTPET imaging is combined with clinical prognostic factors and blood and tissue characteristics to develop models and corresponding nomograms to predict response sufficiently accurate to use in trials and in the clinic.
Study objective
A model based on the combination of clinical prognostic factors and features extracted from tumor contours from CT-PET and biological characteristics obtained from tissue or blood has a high accuracy to predict overall survival and local control after radiotherapy in larynx cancer.
Study design
N/A
Intervention
1. FDG-PET imaging (pretreatment);
2. Blood sampling (facultative);
3. Tissue sampling (facultative);
4. FDG-PET imaging (posttreatment, facultative).
Inclusion criteria
1. Histological proven larynx cancer;
2. Only primary tumors; no recurrences;
3. Only radiotherapy treatment;
4. 18 years or older.
Exclusion criteria
Other pathology then squamous cell.
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| NTR-new | NL2139 |
| NTR-old | NTR2263 |
| Other | Trialnummer Maastro Clinic : 08-31-10/12 |
| ISRCTN | ISRCTN wordt niet meer aangevraagd. |