No registrations found.
ID
Source
Brief title
Health condition
Pancreatic cancer
Sponsors and support
Intervention
Outcome measures
Primary outcome
Invasion of the resected PV-SMV, depth of invasion in the resected PV-SMV, and recurrence and overall survival patterns.
Secondary outcome
Pathological and postoperative characteristics
Background summary
Invasion of the portal vein (PV) or superior mesenteric vein (SMV) in pancreatic cancer is not considered a contra-indication for resection as stated by the International Study Group of Pancreatic Surgery (ISGPS) in 2014.One of the main challenges for a pancreatic surgeon when confronted with possible tumor invasion of the PV-SMV is distinguishing tumor from peritumoral inflammation and fibrosis. Futile venous resection (no invasion of the resected PV-SMV) puts the patients at unnecessary risk for complications. Some studies, with different results, have been conducted regarding the prognostic value of depth of tumor invasion in the resected PV-SMV for overall survival. No studies reported on the prognostic value of depth of tumor invasion for time to recurrence. The aim of this study was to evaluate the number of justified/futile venous resections and correlation between venous resections and recurrence and overall survival patterns.
Study objective
We hypothesize that approximately 2/3 of venous resections are justified by tumor invasion. Future studies on (intraoperative) imaging might help increase the number of justified venous resection. The prognostic value of depth of invasion will help surgeons in counselling patients and possibly apply personalized follow-up.
Study design
Nov 18 - Jan 19: optimize protocol
Feb 19 - May 19: data collection
June 19: first analysis
July 19: first draft of manuscript
Aug 19: final draft of manuscript
Sept 19: submission
Inclusion criteria
Pancreatoduodenectomy from 2010 through 2017 for pancreatic adenocarcinoma
Exclusion criteria
None
Design
Recruitment
IPD sharing statement
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| NTR-new | NL7570 |
| Other | METC LUMC : B18.025 |