No registrations found.
ID
Source
Brief title
Health condition
Epilepsy
Sponsors and support
Intervention
Outcome measures
Primary outcome
We use clinical response to the treatment as a primary endpoint. We will distinguish two groups: Patients with a poor response and patients with a good to excellent response.
Secondary outcome
1. The degree of electrophysiological connectivity between the ATN and the cerebral cortex as measured directly in the phase postoperatively (single measurement)
2. The profile (increase/decrease) of inflammation parameters in peripheral blood over the 2 years after start of the treatment (thus over 4 blood samples in 2 years)
Study objective
Electrophysiological connectivity between ATN and cortical zones involved in the epilepsy of the patient in question relates to treatment response
Study design
0, postoperative, 3, 12, 24 months.
Intervention
This study is a non-interventional study
Inclusion criteria
• Medically refractory epilepsy
• No possibility for resective epilepsy surgery
• Incapacitating epilepsy or seizures
• Pattern of seizures has to be fit for appropriate assessment
• Minimum age 18 years
• Patient or caregiver must be able to register seizures in some way
Exclusion criteria
• Underlying malignancies, whenever life expectancy is lower than 2 years
• Co-medication with anti-inflammatory drugs or systemic diseases with inflammation
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| NTR-new | NL4440 |
| NTR-old | NTR4562 |
| Other | : METC azM/UM nr. 13-2-028 |