No registrations found.
ID
Source
Brief title
Health condition
Complex Regional Pain Syndrome
Sponsors and support
Intervention
Outcome measures
Primary outcome
MitoPO2 and mitoVO2
Secondary outcome
• Demographic parameters such as: age, sex, smoking and consumption of alcohol
• General medical history and medication use
• CRPS severity score
• Videothermography image of the affected and contralateral extremity
Background summary
Complex regional pain syndrome (CRPS) is a complication after trauma or surgery. CRPS is characterized by chronic pain in a distal extremity, usually combined with abnormal sensory, autonomic, motor and/or trophic changes. Temperature asymmetry is common in CRPS. The pathophysiology of vasomotor disturbances in CRPS is still not completely understood. Endothelial dysfunction is one of the underlying mechanisms of vasomotor disturbances in CRPS. Mitochondrial dysfunction is associated with endothelial dysfunction in cardiovascular diseases. It could be possible that mitochondrial dysfunction also plays a role in the pathogenesis of vasomotor disturbances CRPS. The COMET monitor assesses Cellular Oxygen METabolism by measuring cutaneous mitoPO2 and mitoVO2 in humans.
The primary objective is to investigate if there is altered mitochondrial oxygenation and consumption in the skin cells of the affected extremity in patients with CRPS by measuring the mitoPO2 and mitoVO2.
Study objective
Mitochondrial oxygenation and consumption are altered in the affected extremity of patients with CRPS.
Study design
Single measurement
Inclusion criteria
Patients with CRPS
• Diagnosed with CRPS according to the new IASP criteria. We will only include patients that still meet these criteria.
• Clinically the contralateral extremity must be without signs or symptoms in a way that it can be used as a control
• Signed informed consent
Healthy controls
• Signed informed consent
Exclusion criteria
Patients with CRPS
• < 18 years of age
• Presence of mitochondrial disease
• Porphyria
Healthy controls
• < 18 years of age
• Presence of mitochondrial disease
• Porphyria
• (Consideration of) diagnosis of CRPS in history
Design
Recruitment
IPD sharing statement
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| NTR-new | NL8341 |
| CCMO | NL68803.078.19 |