No registrations found.
ID
Source
Health condition
Cancer cachexia
Spierverlies bij kanker
Sponsors and support
Intervention
Outcome measures
Primary outcome
Changes in muscle mass, measured with dexa scan and fiber cross sectional area in muscle biopsy from the vastus lateralis muscle.
Secondary outcome
1. Changes in muscle strength;
2. Changes in endurance capacity;
3. Changes in markers of systemic inflammation and metabolism;
4. Changes in physical activity, diet and quality of life.
Background summary
N/A
Study objective
18 weeks of chemotherapy-treatment results in reduced muscle mass and muscle fiber cross-sectional area, reduced oxidative capacity, reduced muscle strength and increased muscle fat mass.
Study design
All interventions will take place 2 weeks before the start of chemotherapy and after 18 weeks of chemotherapy.
Intervention
All interventions will be performed before and after 18 weeks of chemotherapy:
1. Maximal strength assesment;
2. Maximal cycling test;
3. Muscle biopsy from the vastus lateralis muscle;
4. Venous blood sample;
5. Dexa scan;
6. Questionnaires regarding physical activity, dietary status and quality of life.
De Run 4600
M. Beelen
Veldhoven 5500 MB
The Netherlands
+31 (0)40 8888688
m.beelen@mmc.nl
De Run 4600
M. Beelen
Veldhoven 5500 MB
The Netherlands
+31 (0)40 8888688
m.beelen@mmc.nl
Inclusion criteria
1. Female breast cancer patients;
2. Age between 30-65 years;
3. 18 weeks of chemotherapy treatment with TAC.
Exclusion criteria
1. Participation in an exercise rehabilitation program during the study;
2. Chronic diseases that influence skeletal muscle characteristics, like type II diabetes mellitus, chronic obstructive pulmonary disease, chronic heart failure;
3. Chronic inflammatory disorders, like rheumatoid arthritis, colitis ulcerosa or Crohn's disease;
4. Musculoskeletal disorders that cause an inability to perform exercise.
Design
Recruitment
Followed up by the following (possibly more current) registration
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| NTR-new | NL3281 |
| NTR-old | NTR3449 |
| CCMO | NL40186.015.12 |
| ISRCTN | ISRCTN wordt niet meer aangevraagd. |
| OMON | NL-OMON37832 |