No registrations found.
ID
Source
Brief title
Health condition
Curcumin
Piperine
Genistein
Bioavailability: biologische beschikbaarheid
Oncology: Oncologie
digestive system: maag darmstelsel
blood vessel pathologie; bloedvataandoeningen
Sponsors and support
Intervention
Outcome measures
Primary outcome
The aim of this study is to investigate if curcumin is detectable when patients use curcumin supplements in daily life.
Secondary outcome
Besides curcumin we want to investigate which herbal products or drugs are used by patients, which may be influence the bioavailability of curcumin, such as piperine and perhaps genistein.
Background summary
The aim of the study is to investigate if curcumin is detectable when subjects use curcumin supplements in daily life.
During a single visit to the hospital a questionnaire about the food supplement use by subjects and two blood samples will be collected. One sample before intake and one sample after intake of the food supplement.
With a validated method the concentrations of curcumin, piperin and genistein and their metabolites will be measured.
Study objective
Despite pre-clinical evidence the effectiveness of curcumin in clinical trails is limited. Currently foodsupplements are available as over the counter products with probably fallacious claims about the bioavailability. Prices of 40-50 euros per bottel of curcumin with or without piperin or genistein are common. Despite this patients currently use this supplement in additional care. In this pilot research we want to investigate which products, formulations and dosages patients use and measure the plasma levels reached during intake of these supplements.
Study design
17-okt-2016 start of study
Intervention
none
J.K. Berbee
Meibergdreef 9
Amsterdam 1105AZ
The Netherlands
+31- (0)20-5663871/+31-(0)20-5669111
j.k.berbee@amc.uva.nl
J.K. Berbee
Meibergdreef 9
Amsterdam 1105AZ
The Netherlands
+31- (0)20-5663871/+31-(0)20-5669111
j.k.berbee@amc.uva.nl
Inclusion criteria
Adults, currently using curcumin foodsupplement as a over the counter product, patient in AMC, able to give informed consent, healthy participants/visitors of the AMC
Recruitment method: recruitment via treating physician via a folder. Travel cost will be reimbursed if visit cannot be combined with a regular visit. Personal bloodvalues can be given at the end of the study.
Exclusion criteria
Inability to give informed consent
inability to follow instructions of the investigator
Design
Recruitment
IPD sharing statement
Followed up by the following (possibly more current) registration
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| NTR-new | NL5931 |
| NTR-old | NTR6111 |
| CCMO | NL58755.018.16 |
| OMON | NL-OMON42857 |