No registrations found.
ID
Source
Brief title
Health condition
candidates for brain surgery with epilepsy and/or brain tumours.
Sponsors and support
Intervention
Outcome measures
Primary outcome
The raw recorded MEG signals will be post-processed according to standard procedures, and artefact-free epochs will be selected by an experienced investigator. These epochs are then used to localise underlying neuronal activity using an MEG beamformer, in combination with the patient’s anatomical MRI. A lateralisation index will be computed on the basis of the reconstructed task-related neuronal power changes. In addition, a lateralisation index will be obtained from the Wada procedure by experienced neuropsychologists who are blinded to the MEG results.
Secondary outcome
The lateralisation index computed on the basis of MEG and Wada, respectively, will be compared.
Background summary
To reduce the risk of aphasia or amnesia following surgical resection in patients suffering from epilepsy
and/or brain tumours it is necessary to identify language and memory presentation pre-surgically. Of
importance here is to determine whether there is a dominant hemisphere with regards to language and
memory function. Currently, the gold standard for the evaluation of lateralised language and memory
mapping is the Wada procedure. Recent advances in neuroimaging techniques however might provide us
with opportunities to replace this invasive procedure with a non-invasive and cost-effective alternative to
conduct pre-surgical assessment of language and memory function, and in addition, help in the planning
of grid implantations.
Our overall aim is to create a cost effective non-invasive method of pre-surgical assessment of language
and memory function using MEG scanning. We propose a research project with the key objective to
evaluate the effectiveness of a Dutch implementation of a language/memory stimuli and analysis protocol.
Study objective
Our overall aim is to create a cost effective non-invasive method of pre-surgical assessment of language
and memory function using MEG scanning. We propose a research project with the key objective to evaluate the effectiveness of a Dutch implementation of a language/memory stimuli and analysis protocol.
Study design
After inclusion of the last patient.
Intervention
Language and memory areas will be localised using Magnetoencephalography (MEG). The effectiveness of the protocol will be evaluated by comparison with Wada (intracarotid sodium amobarbital procedure) results.
VU medisch centrum
Receptie C
PK -1 Z kamer 150
de Boelelaan 1118
Alexandra M.E. Linger
Klinische Neurofysiologie/Magneto-encefalografie
VU medisch centrum
Receptie C
PK -1 Z kamer 150
de Boelelaan 1118
Amsterdam 1081 HV
The Netherlands
+ 31 (0) 20 444 0677
alexandra.linger@vumc.nl
VU medisch centrum
Receptie C
PK -1 Z kamer 150
de Boelelaan 1118
Alexandra M.E. Linger
Klinische Neurofysiologie/Magneto-encefalografie
VU medisch centrum
Receptie C
PK -1 Z kamer 150
de Boelelaan 1118
Amsterdam 1081 HV
The Netherlands
+ 31 (0) 20 444 0677
alexandra.linger@vumc.nl
Inclusion criteria
1. Age between 18 and 85;
2. Has had, or will undergo, a Wada test;
3. Will undergo a MEG and MRI scan as part of a pre-surgical evaluation;
4. Written informed consent.
Exclusion criteria
1. Unable to undergo an MRI scan;
2. Insufficient mastery of the Dutch language;
3. Inability to communicate adequately.
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| NTR-new | NL1780 |
| NTR-old | NTR1890 |
| Other | METc VUmc; CWO VUmc; ABR : 09/124; 09-04; NL26907.029.09; |
| ISRCTN | ISRCTN wordt niet meer aangevraagd. |