No registrations found.
ID
Source
Brief title
Health condition
Idiopathic short stature or persistent short stature after being born small for gestational age.
Sponsors and support
Intervention
Outcome measures
Primary outcome
Final height SDS minus initial height SDS.
Secondary outcome
1. Final height SDS;
2. Final height SDS minus initial height SDS;
3. Final height SDS minus target height;
4. Body mass index;
5. Bone mineral density;
6. Quality of life.
Background summary
GH plus GnRHa for 3 years leads to an increase of predicted adult height. At final height an average gain of 4 cm is found (manuscript in preparation).
Study objective
A combined treatment of GH and GnRHa for 3 years in short adolescents with relatively early puberty leads to final height gain.
Study design
N/A
Intervention
Daily injections of Growth Hormone (GH) and monthly injections with GnRHa (Decapeptyl) for 3 years.
Regular controls at the clinic, blood investigations for effect and safety parameters, yearly X-rays of the hand, and yearly psychological assessment.
At final height, growth, psychological assessment, bone mineral density.
Department of Pediatrics,
P.O. Box 9600
J.M. Wit
Albinusdreef 2
Amsterdam 2300 RC
The Netherlands
+31 (0)71 5262824
j.m.wit@lumc.nl
Department of Pediatrics,
P.O. Box 9600
J.M. Wit
Albinusdreef 2
Amsterdam 2300 RC
The Netherlands
+31 (0)71 5262824
j.m.wit@lumc.nl
Inclusion criteria
40 adolescents in early puberty, with a height <-2 SDS or with a height SDS between -1 and -2, but a predicted adult height SDS <-2.
Exclusion criteria
Disorders or medication influencing growth.
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| NTR-new | NL335 |
| NTR-old | NTR373 |
| Other | : N/A |
| ISRCTN | ISRCTN82161629 |