No registrations found.
ID
Source
Brief title
Health condition
dementia, cognition, depression, circadian rhythm, mastication, exercise
dementie, cognitie, depressie, slaap-waakritme, kauwen, bewegen
Sponsors and support
Intervention
Outcome measures
Primary outcome
Improved quality of life.
Secondary outcome
Improvement of (or, slow down the loss of) cognition, mood and circadian rhythm of elderly people suffering from dementia.
Background summary
Exercise is thought to be beneficial for prevention and treatment of cognitive problems, mood disorders and circadian rhythm disturbances in elderly suffering from dementia.
Improved cardiovascular health and increased brain perfusion are considered to be explanatory mechanisms for this effect.
Mastication induces similar bodily responses as exercise, such as increased heart rate, blood pressure and brain perfusion.
Furthermore, impaired mastication (by means of removal of the molar teeth or by offering soft food) negatively effects the performance of mice in maze tasks, and leads to hippocampal neuron loss. Since the hippocampus is associated with both spatial orientation and memory, these findings indicate that impaired mastication leads to memory loss, amongst others. In humans, correlations have been found between mastication and memory, attention and performance on several executive functioning tasks; i.e. when chewing a piece of gum the performance improves.
Study objective
Increased and improved mastication will improve (or, slow down the loss of) cognition, mood and circadian rhythm of elderly people suffering from dementia.
Study design
Base line at 0 weeks;
Follow up at 6 weeks, 3 months, and 6 months.
Intervention
Intervention-Increased masticatory activity achieved through improved oral health care and diet.
Room 1F-58
Roxane Weijenberg
Boechorststraat 1
Amsterdam 1081 BT
The Netherlands
+31 (0)20 5988988
raf.weijenberg@psy.vu.nl
Room 1F-58
Roxane Weijenberg
Boechorststraat 1
Amsterdam 1081 BT
The Netherlands
+31 (0)20 5988988
raf.weijenberg@psy.vu.nl
Inclusion criteria
1. Older than 50 years; suffering from dementia.
Exclusion criteria
1. History of psychiatric disorder
2. Alcohol abuse
3. Cerebral traumata
4. Normal pressure hydrocephalus
5. Neoplasmata
6. Conscious disorders
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
Register | ID |
---|---|
NTR-new | NL1491 |
NTR-old | NTR1561 |
Other | VU University Medical Center : 2504931 |
ISRCTN | ISRCTN wordt niet meer aangevraagd |