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ID
Source
Brief title
Health condition
Sarcopenia and malnutrition
Sponsors and support
Intervention
Outcome measures
Primary outcome
Muscle strength measured by the 1-RM
Secondary outcome
- cognitive ability
- body composition
- muscle architecture
- inflammation markers, glucose and insulin levels
- physical performance
- handgrip strength
- activities of daily living
- quality of life
- malnutrition
- daily dietary intake
- daily physical activity
- cognitive performance
- psychosocial outcomes
- cost-effectiveness
- adverse events / medical status
- adherence
- process evaluation
Background summary
The world population is aging rapidly. As society ages, the incidence of physical limitations and frailty is dramatically increasing, which reduces the quality of life and increases health care expenditures. An important cause of physical limitations and frailty is the age-related loss of skeletal muscle mass, strength and performance, also referred to as sarcopenia.
Resistance-type exercise training is the most promising intervention to prevent or treat sarcopenia in older adults. Evidence of resistance exercise is based on well-controlled studies and cannot be easily translated to daily physiotherapy practice. In practice, the execution of the training protocol differs tremendously among older adults and depends on various resistance exercise training variables (e.g. load, repetitions and volume) and personal characteristics such as frailty status, gender, age, co-morbidity, nutritional status and cognitive and mental performance. As such, physiotherapists are limited in using the available training recommendations and are in need for more personalized training protocols that improve sarcopenia outcomes. In addition, dietary protein intake is suggested to be adequate to further improve sarcopenia outcomes during resistance exercise in frail older adults. More research is warranted on the impact of (in)adequate protein intake on training adaptations and sarcopenia outcomes.
Study objective
This study will find the most effective and optimal resistance exercise training program for frail older adults, and takes into account (in)adequate protein intake and personal characteristics, in order to improve sarcopenia-related outcomes in this heterogeneous population.
Study design
- screening
- week 0: baseline measurements
- week 1: 1-RM (start of intervention)
- week 4: 1-RM
- week 8: 1-RM
- week 12 & week 13: final measurements (End of Study)
Intervention
Resistance exercise training
Blended dietary counseling
Mohammed Benali
+31(0)642100294
m.benali@hva.nl
Mohammed Benali
+31(0)642100294
m.benali@hva.nl
Inclusion criteria
- Community-dwelling and-or independent living, receiving in-home care services
- Aged 65 or older
- Physical ability and willingness to execute a resistance exercise program
- Ability and willingness to comply with the protocol
- Willingness that general practitioner will be notified on study participation
- Written informed consent
- Consent of the study physician
Exclusion criteria
- Inability to understand the Dutch language
- Cognitive impairment (MMSE < 15)
- Diagnosed unstable coronary heart disease (CHD), decompensated heart failure, uncontrolled hypertension or uncontrolled arrhythmias (e.g. hart failure NYHA >3)
- Diagnosed degenerative neurocognitive disorders
- COPD GOLD >3
- Use of total parenteral nutrition (TPN)
- Active medical treatment interfering with this intervention (e.g. cancer patients following systemic and immune therapy)
- Physical disabled (walking aids or mild visual impairment are not an exclusion criteria)
- Current enrollment in a fixed rehabilitation program or other intervention studies
- Palliative treatment or a life expectancy of ≤ 3 months
Design
Recruitment
IPD sharing statement
Plan description
Followed up by the following (possibly more current) registration
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Other (possibly less up-to-date) registrations in this register
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In other registers
| Register | ID |
|---|---|
| NTR-new | NL8785 |
| Other | METC VUmc : 2020.452 |