No registrations found.
ID
Source
Health condition
Leptomeningeal metastases among breast cancer patients
Nederlands:
Leptomeningeale metastasen bij patienten met mammacarcinoom.
Sponsors and support
Intervention
Outcome measures
Primary outcome
The detection rate of leptomeningeal metastases as the presence of at least 1 CSFCT in liquor (independent of volume) by the CellSearch method in patients with negative CSF cytology.
Secondary outcome
Molecular analysis of CSFCT and CTCs
Background summary
Currently available diagnostic techniques to diagnose LM are hampered by low sensitivity. In this pilot, we aim to improve the detection rate of LM in breast cancer patients by using the CellSearch technique, quantifying circulating tumor cells (CTCs) in cerebrospinal fluid and compare it with the current standard of care; i.e. cytopathological examination. We hypothyze that the detection rate of the CellSearch technique is higher compared to cytology.
Study objective
The detection rate of leptomeningeal metastases with the CellSearch technique is higher compared to cytology.
Study design
Additional liquor will be sent to the laboratory to detect and quantify tumor cells by the CellSearch technique.
Blood draw, preferably during a blood draw that was already necessary for standard care.
Intervention
Draw extra liquor for CSFCT during regular LP.
A. Jager
Groene Hilledijk 301
Rotterdam 3075 EA
The Netherlands
Tel 010 704 17 33
a.jager@erasmusmc.nl
A. Jager
Groene Hilledijk 301
Rotterdam 3075 EA
The Netherlands
Tel 010 704 17 33
a.jager@erasmusmc.nl
Inclusion criteria
- Breast cancer patients with clinical suspicion of leptomeningeal metastases (LM) who are planned to undergo a lumbar puncture to confirm/exclude the diagnosis LM.
- Signed informed consent.
Exclusion criteria
- Contra-indication for lumbar puncture (on the discretion of the treating neurologist).
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| NTR-new | NL5408 |
| NTR-old | NTR5533 |
| Other | : MEC15-419 |