41 results
The goal of this study is to investigate which treatment(-s) lead to the best outcome by using existing variation of practice.
Objective 1: To improve the understanding of the dynamic phenotypic spectrum and the disease mechanisms of HD by:a. collecting natural history data covering the cognitive, behavioral and motor domains permitting estimates of rates of progression in…
To evaluate RRS with delayed RRO as an alternative for RRSO in BRCA1/2 gene germline mutation carriers. We hypothesize that RRS with delayed RRO leads to an equal ovarian cancer incidence when compared to RRSO.
To investigate whether tear biomarkers can differentiate between patients and controls, and between patient groups.
First, to establish the yield of the currently propagated pancreatic cyst surveillance program, and second, to identify possible alternative surveillance strategies, which might be more (cost) effective.
This strategy will result in a reduction reduce the incidence of major adverse cardiovascular events (MACE) defined as death or non-fatal myocardial infarction and appear more efficient than care as usual.
The aim of the COGENIUS trial is to investigate the effect of the two types of RF treatment on individuals experiencing chronic knee pain that is resistant to conservative treatments. For this purpose, the efficacy and cost-effectiveness of cooled…
Our objective is to compare the efficacy of early chest tube removal combined with single-shot PVB versus standard treatment (chest tube for at least 3 days and thoracic epidural analgesia (TEA)) after surgery for PSP. Efficacy is defined as…
Primary objective is to study the antibody immune response to routine vaccinations in very preterm infants (GA<32 weeks). Secondary aim is to study the immune system more extensively using flow cytometry, ELISA and single cell…
To compare safety and efficacy of treatment with sentinel lymph node biopsy guided elective neck irradiation versus standard elective neck irradiation in patients receiving definitive (chemo)radiotherapy for squamous cell carcinoma of the…
To determine whether CDT in high-risk PE relative to systemic thrombolysis is:- more effective and safer in terms of a reduction of the composite endpoint on all-cause mortality and adverse events defined as treatment failure, major&…
The main objective of the study is to optimize the use and user-friendliness of the voice analysis program, which could potentially help with the early detection of acute deterioration in heart failure. Hopefully, we can develop a technique that…
The main aim of the current study will be to determine the metabolic fate of dietary protein. More specifically, the main aim is to assess the incorporation of protein-derived amino acids in a wide variety of organ tissues in vivo in humans.
To demonstrate that in post-MI patients with symptomatic heart failure who receive optimal medical therapy (OMT) for this condition, and with reduced LVEF <=35%, OMT without implantable cardioverter defibrillator (ICD) implantation (index…
rTMS is an intensive but effective treatment that could benefit from further optimization. Cognitive control training (CCT) engages the same underlying neural circuitry as rTMS and has been shown to improve therapeutic response (Koster et al., 2017…
The primary objective of this study is to compare the mean binocular DCIVA at 66 cm under photopic conditions 3 months after cataract surgery, in a series of patients, who previously underwent myopic laser surgery, bilaterally…
Primary objective: 1. To validate the data quality and diagnostic accuracy of StrokePointer to detect LVO stroke among patients with a suspected stroke in the pre-hospital setting. Secondary objectives:1. To determine the user-…
Our primary objective in this study is to predict treatment outcome for SSRI, CBT, rTMS, esketamine, and ECT in patients with MDD with the use of biomarkers and machine learning using data obtained before a new or follow-up treatment. Our secondary…
A pilot study on digital coaching in rUTI at the Urology Department of Isala tested an app-based treatment additional to standard care.[8] The app provides information on rUTI aetiology, lifestyle recommendations, treatments, and the value of…
Objective: To identify and characterize WD patients in the Netherlands. Secondary objectives of this study are; describe disease management and treatment patterns, examine treatment adherence and efficacy of current treatment options, gain insight…