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(Cost) Effectiveness of Surgery versus Prolonged Conservative Treatment in Patients with Intermittent Neurogenic Claudication caused by Lumbar Stenosis

Intermittent neurogenic claudication due to lumbar stenosis is frequently diagnosed among older persons. Due to an aging population it is to be expected the incidence of lumbar stenosis will increase over time. Patients are operated on because of…

The effect of Local Infiltration Analgesia on postoperative pain in Total Knee Arthroplastia

Reduction of the postoperative pain in Total Knee Arthroplatia through the use of a peri- and intracticular injection of Local Infiltration Analgesia.

Ventricular Tachycardia Ablation vs. ENhanced Drug Therapy In Structural Heart Disease

To compare aggressive antiarrhythmic drug therapy to catheter ablation (ablation) for ventricular tachycardia (VT) in patients who have suffered prior myocardial infarction.

The effectiveness of a microscope during apical surgery; a prospective randomized controlled blinded clinical trial.

The objective of this study is to assess whether or not apical surgery that is carried out with the help of a microscope has a higher success rate than apical surgery without the use of a microscope. No RCT is found in present literature (Del Fabbro…

Long term follow up of the clinical and immunological responses following HPV 16 E6/E7 synthetic long peptides vaccination in women with HPV 16 positive vulvar intraepithelial neoplasia grade 3

To determine the long term clinical and immunological responses in patients with high grade VIN who have been vaccinated with an HPV 16 E6/E7 SLP vaccine approximately 3 years ago.

A randomized, double-blind, cross-over trial of two speech coding strategies in cochlear implantation

Hypothesis: PLS will improve speech understanding in noise in comparison to HiRes, an exisiting state-of-the-art speech coding strategy. The objective is to test this hypothesis. A secondary hypothesis is that PLS improves pitch perception. A…

A pivotal trial of safety and efficacy of ADRCs delivered via the intracoronary route in the treatment of patients with ST-elevation acute myocardial infarction â¤* The ADVANCE Trial

The objective of this study is to determine the Safety and Efficacy of ADRCs delivered via the intracoronary route in the treatment of patients with ST-elevation acute myocardial infarction (STEMI).Investigation of stem and regenerative cell therapy…

An open-label, two period study to determine the excretion balance and pharmacokinetics of 14C-GSK573719, administered as single dose of an oral solution and an intravenous infusion, to
healthy male adults

The purpose of the study is to investigate how quickly and to what extent GSK573719 is absorbed, distributed, metabolized (broken down) and eliminated from the body (this is called pharmacokinetics). The compound to be administered will be labeled…

Pilot-study: Investigation of the safety of irreversible electroporation (IRE) as novel treatment for colorectal liver metastases - a phase I clinical study

The primary objective of this study is to evaluate the safety in terms of complication rate of IRE in the treatment of colorectal liver metastasis/es <3,5 cm in patients undergoing surgical resection (metastatectomy, segmental liver resection…

The effectiveness and evaluation of the online 'Kanker Herstel Hulp' intervention in cancer survivors.

The project primarily aims to study short (3 and 6 months) and long term (12 months) health related effects of the 'Kanker Nazorg Wijzer' on survivors' psychosocial distress and quality of life (QoL). Furthermore, process aspects of…

An outpatient phase 3 efficacy study of Ecopipam (PSYRX 101) in the symptomatic treatment of self-injurious behavior in subjects with Lesch-Nyhan disease.

The primary objective of this study is to assess the efficacy of Ecopipam to reduce self-injurious behaviors (SIB) in adults and children with Lesch-Nyhan Disease (LND) in an outpatient setting. The secondary objectives of this study are to assess…

Assessment of the Photopill Capsule Treatment for safety and feasibility in healthy volunteers, a phase 1 trial

The evaluation of the safety and feasibilty of the Photopill capsule treatment in healthy volunteers, a phase 1 trial

Influence of changes in brain activity during movement observation and execution on the recovery of motor function after stroke.

The objective of the study is to examine the relation between changes in cortical activity during movement observation and execution, and changes in motor function and motor control after stroke. The hypotheses to study this objective are: 1. Brain…

Cognitive aging and neuroplasticity: prefrontal compensatory mechanisms during working-memory performance

The primary objective is to establish whether prefrontal compensatory mechanisms during working-memory performance may be enhanced by working-memory training, both in healthy older adults and MCI patients. The secondary objective is to establish age…

Effect of oral exposure duration and gastric energy content on gastric emptying rate

The primary objective of this study is to investigate the effect of - short vs. long - oro-sensory exposure combined with a gastric load - low vs. high in energy -, on gastric emptying rate. As secondary outcome we want to investigate the effect of…

Effects of a nurse coordinated program of lifestyle improvement aimed at reducing the risk of recurrent cardiovascular events in patients who have suffered an acute coronary syndrome.;RESPONSE2: (Randomised Evaluation of Secondary Prevention by Outpatient Nurse SpEcialists 2)

Primary Objective: To determine the effectiveness of a comprehensive lifestyle intervention program aimed at reducing the risk of recurrent cardiovascular events in patients who have suffered an acute coronary syndrome.Secondary Objective:…

MEA115575: A Randomised, Double-Blind, Placebo-Controlled, Parallel-Group, Multicenter Study of Mepolizumab Adjunctive Therapy to Reduce Steroid Use in Subjects with Severe Refractory Asthma (MEA115575)

Primary: To compare the effects of mepolizumab adjunctive therapy with placebo on reducing the use of maintenance oral corticosteroids (OCS).Secondary: Safety, tolerability, other efficacy parameters, quality of life.

Prophylactic infusion of CD4 positive donor lymphocytes early after T-cell depleted allogeneic stem cell transplantation in patients with an unrelated donor

In this phase II study, the toxicity and treatment effects of early donor derived CD4+ lymphocyte infusion, three months after allo-SCT, will be evaluated

500NL project

The aim of the study is to test the hypothesis that susceptibility to and severity of certain infectious and inflammatory diseases can be explained by the interaction between the genome, microbiome and immunological responses: i.e. presence of…

Peroperatieve researchstudy with de ROTEM machine to hemostase of patients during aorta abdominalis aneurysm operation.

Objective of the study:Investigating with use of the classical coagulation tests on one hand and with the ROTEM on the other hand what is exactly becoming disturbed in the coagulaton because of bleeding during surgery of the aorta abdominalis,…