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Immune sparing Radiotherapy strategies In head and neck Squamous cell carcinoma (IRIS)

To study the immune effects of novel radiotherapy schedules by longitudinal immune profiling. There will be a specific focus on actionable immune targets and their temporal patterns that can be tested in future immune-radiotherapy combination trials…

An interventional, prospective IVD device study for the testing of DNA extracted from tumor tissue biopsy samples in a first line setting from patients diagnosed with metastatic Colorectal Cancer (mCRC) to determine the KRAS G12C mutation status as part of the inclusion criteria into the Amgen Phase III clinical trial (Protocol No 20210081) to demonstrate clinical performance of the therascreen® KRAS RGQ PCR Kit.

To utilize the therascreen KRAS RGQ PCR Kit, as a screening test in Amgen*s Phase 3 Clinical Study Protocol 20210081, in order to identify patients with mCRC KRAS G12C mutation positive tumors to be enrolled in the drug clinical trial. Results of…

Physical prehabilitation in patients with head and neck cancer scheduled for a laryngectomy; a feasibility study

The aim of this study is both a feasibility study to gain a comprehensive understanding of the feasibility, satisfaction and impact, and trends of the effects of a physical exercise and nutritional intervention in patients who will be treated by a…

The effect of an extended use of enteral tube feeding sets on growth of microorganisms

Primary objective of the study is to determine whether prolonged use of 96 hours leads to growth of microorganisms (type and numbers (CFU/ml)) in enteral tube feeding sets. Secondary objectives are the occurrence of gastrointestinal events/ new…

Feasibility and validity of the use of a new arm leg ergometer for exercise testing in persons with limited lower limb function: a pilot study

The goal of the current study is to evaluate both the feasibility and validity of the Corival ALT prototype for exercise testing in patients with lower limb deficits.

Deliver mOre aPplications for more durable Pulmonary vein IsOlation with the Pentaspline Pulsed Field Ablation catheter, the DOPPIO trial

to determine if freedom of AF may be improved by delivering more, and targeted PFA applications while avoiding side-effects of higher PFA dosing.

Effects of butyrate on depressive symptoms and affect in depression - a pilot randomized controlled trial

The primary objectives are to study the feasibility and acceptability of an 8-week daily oral supplementation with tributyrin (4 g/day) - the triglyceride form of butyric acid - on top of treatment as usual (TAU) in adults (18 up to 65 years) with…

MOVADECT

MAIN GOAL: We will integrate population-level registry (CBS) data and data from a survey on beliefs, values, and behavior to build a model to predict SARS-CoV-2 vaccination uptake on a population and local level. This model will take into account…