7 results
To study the kinetics of the vaccine-induced antibody response against HPV16/18 after a two-dose schedule by measuring these antibody responses at approximately 7, 12, 24, 36, 48, 60, 72, 84, 96, 108 and 120 months following the first dose of HPV-…
The primary objective is to estimate product-specific vaccine effectiveness (VE) of the COVID-19 vaccines that are used in the Dutch national vaccination program against symptomatic SARS-CoV-2 infection by age and medical risk group at a time point…
The objective of this study is to deep phenotype CIndU (subtype SD and ColdU) and detect novel biomarkers for diagnosis and treatment response as well as establish methodologies for (non-) invasive monitoring of treatment effects in chronic…
Primary objective• Assess the ability of donepezil to reverse biperiden-induced effects on adaptive tracking performance at timepoint 4h Secondary objectives• Evaluate the PK of donepezil and biperiden• Investigation of pro-cholinergic effects of…
Primary Objectives: Quantify the PD effects of CNS active compounds with distinct mechanisms of action (lorazepam, modafinil and S-ketamine) with NeuroKit and NeuroCart in healthy male and female participants. Estimate the…
In this study, we investigate how two new measurement methods can demonstrate the effects of two existingdrugs, modafinil and alprazolam, on the excitability of the brain. We test these effects only in healthy subjects.The effects of modafinil and…
The main objective of this study is to establish a controlled human infection model for Chikungunya using the VLA1553 vaccine.Primary objectives:- To assess the infection rate induced by a single administration of the VLA1553 vaccine- To assess the…