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Melanoma Margins Trial-II: 1cm v 2cm Wide Surgical Excision Margins for AJCC Stage II Primary Cutaneous Melanoma (MelMarT-II)

This study will determine whether there is a difference in disease free survival for patients treated with either a 1cm excision margin or 2cm margin for clinical stage II (pT2b-pT4b) primary cutaneous melanoma (AJCC 8th edition, Table 1). The…

A Pre-Market, First-In-Human, Pilot, Interventional, Clinical Investigation to Evaluate the Safety of the Aqua Therapeutics Thermal Therapy Vapor Ablation System (ATTTVAS) in premenopausal women with Abnormal Uterine Bleeding (AUB).

Primary ObjectiveTo evaluate the safety of the Aqua Therapeutics Thermal Therapy Vapor Ablation System (ATTTVAS).Secondary Objectives1. To evaluate the change of menstrual blood loss (MBL).2. To evaluate the effect of MBL on the quality of life (…

Dolphin CONTINUE: A nutritional intervention aimed at improving neurodevelopmental outcome in infants at risk for or with early life brain injury

The main objective is to study the effect of the nutritional intervention versus the control product on white matter development (as assessed using tract based spatial statistics of fractional anisotropy) using a DTI scan at the corrected age of…

Evaluating the Feasibility of a Gamified Lifestyle Change Intervention for Patients with Symptomatic Atrial Fibrillation (EHRA Class IIb or Higher): GAMES4CARE.

The primary objective of this study is to evaluate the adherence to a 3-month gamification intervention integrated with a recently developed platform for continuous lifestyle monitoring (Care-On) in patients with recurrent atrial…

Evaluation of popliteal artery entrapment in healthy individuals

To investigate in healthy individuals not having ELP whether DUS and dynamic MRI may reveal a compressed popliteal artery in rest and during provocative testing (pointing, plantar foot flexion).

HASTA study - Healthy Aging starts with a healthy STArt;Remote electrophysiological cardiotocography (eCTG), evaluation of feasibility in (a selected group of) complicated pregnancies from 32 until 37 weeks gestational age in a Home@Hospital setting: a prospective cohort study

To evaluate the feasibility of remote eCTG monitoring in complicated pregnancies between 32-37 weeks in a Home@Hospital setting. Secondary objectives are to evaluate automated interpretation of remote eCTG monitoring and to assess perinatal and…