2438 results
To monitor the systemic effects of radiotherapy (RT) alone or in combination with concurrent chemotherapy (CRT) (Cisplatin) on the immune response and T-cells over time in patients with HPV+ head and neck squamous cell carcinoma (HNSCC).
To evaluate the efficacy of VX-661 in combination with ivacaftor and ivacaftormonotherapy through 8 weeks of treatment in subjects with cystic fibrosis (CF)who are heterozygous for the F508del mutation on the CF transmembraneconductance regulator (…
To evaluate the efficacy of JZP-110 administered once daily for up to 12 weeks in doses of 75, 150, and 300 mg compared to placebo in the treatment of excessive sleepiness in adult subjects with narcolepsy.
To demonstrate the efficacy of ponatinib administered at 2 starting doses (30 and 15 mg QD) compared to nilotinib administered at 400 mg BID in patients with CP-CML who are resistant to imatinib, as measured by MMR by 12 months
This proof of principle study is designed to study the excretion of two well-studied transporters, Aquaporin-2 (AQP-2) and the sodium chloride cotransporter (NCC), in urinary exosomes. Both are sensitive to water homeostasis, so that during water…
The main aim of this phase-II-proof-of-principle study is to test whether the health game AquaSnap offers improvement of cognitive impairment in PD patients with mild cognitive impairment, using an RCT. The long-term ambition is to test whether the…
Primary objective: To compare the anti-hypertensive response to dietary salt restriction with the anti-hypertensive response to the diuretics hydrochlorothiazide/amiloride in patients with CKD stages 3 or 4. Secondary objectives: * To analyze the…
Primary objectiveTo determine whether adding the MRI/US fusion technique using mpMRI images for directed biopsy of a ROI leads to a higher detection rate of PCa per patient compared to a systematic 12-core biopsy protocol including directed biopsy…
Study of functional outcome after arthroscopic tenotomy of long head biceps tendon vs. arthroscopic debridement vs. conservative treatment as treatment for degenerative rotator cuff ruptures in patients 65 years or older.
Primary Objective:To demonstrate that the AlCath Flux eXtra Gold ablation catheter is non-inferior compared to historical datafrom the literature regarding the prevention of new subclinical cerebral thromboembolic lesions after PVI.Secondary…
The purpose of the study is to investigate to what extent FE 201836 is tolerated. It will also be investigated how quickly and to what extent FE 201836 is absorbed and eliminated from the body (this is called pharmacokinetics). Also the effect on…
The primary objective is to study the effect of sensor monitoring embedded in an OT rehabilitation program for older persons after hip fracture on recovery of daily functioning, 6 months after the start of rehabilitation, as compared to coaching by…
To develop TMS-EEG as a technique to study the interaction between brain regions. The specific experiments in this study are aimed at investigating the effects of brief activations of specific brain regions using TMS on signals recorded non-…
Documentation of the patients' functional recovery and quantification of fusion after implantation of 3-D trabecular titanium cages on the short and long term. These data will be compared with the recently performed randomized CASCADE trial on…
Primary objectives:• To assess the safety and tolerability of induction doses of ABP-700 • To optimize induction dosing of ABP-700 in combination with pre-medicationsSecondary objectives:• To characterize the pharmacokinetics (PK) of ABP-700 and its…
For head and neck (H&N), lung and esophageal cancer, an initial simple screening test would involve interrogation of the buccal mucosa. There are several tissue alterations related to field carcinogenesis that are currently undetectable but…
Primary objective1) To study the frequency of mutations in this gene in patients with central hypothyroidism and their first- and second-degree relativesSecondary objective: 2) To determine the clinical, biochemical and radiological consequences of…
Currently, caplacizumab is being developed for treatment of acquired thrombotic thrombocytopenic purpura (TTP). TTP is a rare and potentially life-threatening thrombotic microangiopathy, in which accumulation of ULvWF multimers leads to an increased…
- To evaluate the bladder-preservation rate after chemoradiation - To evaluate the toxicity and complications of treatment with induction chemotherapy followed by ePLND and chemoradiation
The primary objective of the study is as follows:· To compare the rate of asthma exacerbations between patients with low baseline periostin levels (< 50 ng/mL) and patients with high baseline periostin levels (* 50 ng/mL), as measured by…