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Evaluation of the Neurologic Assessment in Neuro-Oncology (NANO) criteria among brain cancer patients

The development of an objective, standardized and validated tool for the assessment of clinical outcome of brain tumor patients

Heart Failure and Related Risk Factors after Preeclampsia

Part I- To determine the impact of PE on incidence of macro-and micro-vascular dysfunction reflected by surrogate measures for coronary artery disease (CAD) and HFpEF, and potential deterioration over time.- To perform a genome wide association…

Brain function in macro- and micro-networks - an ECoG/stereo-EEG and fMRI approach

In the current proposal, we address four primary objectives:- Assess the precise relationship between hemodynamics and neuronal activity- Investigate the possibilities for high-dimensional brain decoding for ECoG(stereo-EEG)-BCI - Establish whether…

Randomized open label study to compare the efficacy and safety of everolimus followed by chemotherapy with STZ-5FU upon progression or the reverse sequence, chemotherapy with STZ-5FU followed by everolimus upon progression, in advanced progressive pNETs (SEQTOR study)

The purpose of this study is to compare STZ vs everolimus as first line treatment for advanced pNET and elucidate which sequence of STZ based chemotherapy and the mTOR inhibitor, everolimus, gives better results in terms of PFS in well…

A Phase 3, Randomized, Open-Label Study of Nivolumab Combined with Ipilimumab Versus Sunitinib Monotherapy in Subjects with Previously Untreated, Advanced or Metastatic Renal Cell Carcinoma

This study has been transitioned to CTIS with ID 2023-504761-23-00 check the CTIS register for the current data. The co-primary endpoints of this study are PFS in intermediate and poor-risk subjects, as assessed by an Independent Radiology Review…

Looking into the eye of ADHD. Investigating the relationship between ADHD, the delayed circadian rhythm and the functioning of the eye.

The aim of this project is to investigate associations between visual system functioning, ADHD, and the circadian rhythm. We will also investigate the effects on the functioning of the visual system of commonly used treatments for ADHD and related…

Linking multimodal network imaging and cognitive functioning in glioma patients

The current study aims to primarily investigate associations between multimodal networks in glioma patients. Secondary objectives include investigation of the correlations between multimodal neural networks and cognition and epilepsy and linking…

A Phase 1b Open-label Study to Evaluate the Safety and Efficacy of CC-122 in Combination with Obinutuzumab (GA101) in Subjects with Relapsed/Refractory Diffuse Large B-Cell Lymphoma and Indolent Non-Hodgkin*s Lymphoma

Primary Objectives:• Determine the safety and tolerability of CC-122 administered in combination with obinutuzumab.• Determine the non-tolerated dose (NTD), maximum tolerated dose (MTD), and recommended Phase 2 dose (RP2D) of CC-122 administered in…

Effectiveness of neurolysis versus neurectomy of the lateral femoral cutaneous nerve (LFCN) in the treatment of meralgia paresthetica.

The goal of the stomp trial will be to investigate the effectiveness of both the neurolysis and neurectomy procedure in patients with persistent symptoms of meralgia paresthetica. In addition, in this trial we want to determine to what extend…

Pancreatic Locally advanced Irresectable Cancer AblatioN (PELICAN trial)

The aim of the PELICAN trial is to investigate the survival benefit of RFA followed by chemotherapy as compared to standard palliative chemotherapy alone in patients with LAPC.

A prospective study to evaluate long-term clinical outcomes of the GTS
cementless femoral stem

The objectives of this prospective clinical study are:1. Obtain multi-center, long-term (10-year) clinical data on the new GTS® femoral stem inits standard and lateralized versions2. Collect quality of life data

A randomized double-blind, placebo-controlled study of LEE011 in combination with letrozole for the treatment of postmenopausal women with hormone receptor positive, HER2-negative, advanced breast cancer who received no prior therapy for advanced disease (CLEE011A2301)

Primary objective: Progression free survival (PFS) of treatment with letrozole plus LEE011 compared to treatment with letrozole plus placebo .Secondary objectives: Overall survival (OS), overall response rate (OR), overall clinical benefit rate,…

A phase I, multicenter, open-label study of oral ABL001 in patients with chronic myelogenous leukemia or Philadelphia Chromosome-positive acute lymphoblastic Leukemia (CABL001X2101)

Primary:Determine the MTD and/or RDE(s) of ABL001:* As a single agent for CML CP and AP patients* In combination with either nilotinib or imatinib or dasatinib in CML CP and AP patients* As a single agent for CML BP patients and Ph+ ALL…

Immunogenicity of Tumor Organoids derived from colorectal, gastric, gynaecological and non-small cell lung cancer, a Feasibility Study

Establish the immunogenicity of tumor organoids in vitro

The development of electrophysiological readouts for migraine attack prediction

The overall objective of this study is to combine a conceptual model with empirical evidence to demonstrate that the start of a migraine attack corresponds to a critical transition that occurs when the dynamical brain system approaches a tipping…

Monitoring Outcomes of Psychiatric Pharmacotherapy

In the project *Monitoring Outcomes of Pharmacotherapy (MOPHAR), an infrastructure will be created in which - using standardised protocols - longitudinal monitoring data will be collected regarding Routine Outcome Monitoring (ROM), medication usage…

Treatment strategies in colorectal cancer patients with initially unresectable liver-only metastases. CAIRO5 a randomized phase 3 study of the Dutch Colorectal Cancer Group (DCCG)

To determine the median progression-free survival (PFS) and R0/1 secondary resection rate upon induction systemic treatment in colorectal cancer patients with initially unresectable liver-only metastases, stratified by RAS and BRAF tumor mutation…

Efficacy of alternating immunochemotherapy consisting of RCHOP + R-HAD versus R-CHOP alone, followed by maintenance therapy consisting of additional lenalidomide with rituximab versus rituximab alone for older patients with mantle cell lymphoma

Primary objective:To evaluate whether the addition of lenalidomide to rituximab-maintenance improves progression free survival (PFS) compared to standard rituximab maintenance after response to induction chemotherapy in older patients with mantle…

Acceptance and commitment therapy as an intervention to improve quality of life and activity-engagement in patients with multiple sclerosis.

The purpose of the current study is therefore to investigate the effectiveness of an ACT group intervention on both activity engagement and QoL in MS patients in comparison with a waiting list condition. Furthermore, we hypothesize that…