1679 results
Long-term safety and pharmacokinetics (PK) of neoGAA
The main objective of this study is to gain insight in the (reverse) remodeling process of the atria in patients with atrial fibrillation. T Analyses will be conducted on the cardiac tissue and blood samples. We aim to correlate the findings from…
To test whether monthly infusions (every four weeks) of intravenous Flebogamma® 5% DIF in a 1 year treatment period in PPS subjects are superior to placebo by assessing physical performance, as measured by 2MWD.For Stage 1, to select the optimal…
Objective 1: To improve the understanding of the dynamic phenotypic spectrum and the disease mechanisms of HD by:a. collecting natural history data covering the cognitive, behavioral and motor domains permitting estimates of rates of progression in…
Currently, there are no curative treatment options for patients with Waldenstrom*s macroglobulinemia (WM) and there is no consensus on standard first line or relapse treatment. The proteasome inhibitor bortezomib has shown efficacy in WM, but is…
Objectives: The primary objective of this study is to evaluate the effect of response to treatment (assessed by SVR12 status) on the long-term progression of liver disease in adults with chronic HCV GT1 infection who received treatment with ABT-450/…
The main objective of this study is to demonstrate treatment efficacy of MR-HIFU ablation of breast cancer. Effective treatment is defined as 100% necrosis of the targeted primary breast tumor. The secondary objective is safety of the MR-HIFU…
In 2004, a multidisciplinary team of clinicians and researchers in the UZ Leuven hospital started to collaborate on the rare problem of cancer during pregnancy. The collaboration between gynaecologists, pediatricians, hematologists, farmacologists,…
The main objectives of this project are:- To start a prospective observational cohort study of patients who have been diagnosed with CRC, small bowel and anal cancer and follow them from time of diagnosis until death.- To prospectively collect data…
This study has been transitioned to CTIS with ID 2024-518559-41-01 check the CTIS register for the current data. The main objectives are to identify markers for amyloid pathology in cognitively normal subjects, to identify risk factors for amyloid…
In phase I safety and pharmacological properties of GDC-0032 in combination with tamoxifen in patients with advanced solid tumors will be investigated. The effectiveness of GDC-0032 in combination with tamoxifen will be studied in patients with…
Aim of the study is to show the feasibility of pneumatic tube transport of thrombocyte concentrates. The efficacy will be measured by thrombocyte increment (CCI) and thrombocyte funtion analysis. This shall lead to routine transportation of TC*s to…
We want to examine the effect of the antihistamine Ebastine on abdominal pain and other symptoms associated with IBS and the quality of life. Through this research we would like to emphasize that this study primarily focuses on improvements of the…
Systems biology is an interdisciplinary approach that systematically describes the complex interactions between all the parts in a biological system, with a view to elucidating new biological rules capable of predicting the behavior of the…
The purpose of this study is to document the short-, mid- and long-term safety and efficacy of the Journey II BCS knee prosthesis. The goal of this study is to confirm the safety and efficacy of the Journey II BCS knee prosthesis by demonstrating…
The primary objective is to compare the efficacy of daratumumab when combined with lenalidomide and dexamethasone (DRd) to that of lenalidomide and dexamethasone (Rd), in terms of progression-free survival (PFS) in subjects with relapsed or…
At the brain system level, we seek to investigate whether neural response patterns obtained by fMRI, MEG EEG, t(A/D)CS and fNIRS can reveal the neural and physiological mechanism behind cognitive processes in general, more specifically per study…
The purpose of UCC-SMART is to create multidisciplinary care of patients with cardiovascular disease and to create at the same time, by building a vascular cohort, a scientific infrastructure. The main questions of UCC-SMART are:* What is the risk…
1. To comprehensively describe: a) the functions, activities, participation, and quality of life of stroke survivors on the short and long term; b) the structure and process of in- and outpatient stroke rehabilitation; c) the stroke patients*…
To investigate the possibility of using low dose peri-tumoral Magtrace® injection for a complete magnetic, radiation free, procedure for sentinel lymph node (SLN) detection and evaluation. This objective, can be sub-divided in the following…