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A Randomised, Double-Blind, Placebo-Controlled, Multicentre Phase II Study to Compare the Efficacy, Safety and Tolerability of Olaparib Versus Placebo When Given in Addition to Abiraterone Treatment in Patients With Metastatic Castrate-Resistant Prostate Cancer Who Have Received Prior Chemotherapy Containing Docetaxel

Primary:To compare the efficacy of olaparib when given in addition to abiraterone, with placebo givenin addition to abiraterone, by assessment of radiologic progression-free survival (rPFS) usingResponse Evaluation Criteria in Solid Tumours version…

Comparison of Zimmer Maxera Acetabular System to the Allofit Cup with Roentgen Stereophotogrammetric Analysis (RSA) in Total Hip Arhtroplasty

To perform a comparative assessment between the clinical and radiographic outcomes (as measured with RSA) of the Maxera Ceramic cup versus the standard uncemented polyethylene Allofit Cup all combined with the ML Taper stem in patients undergoing…

I CARE STUDY; Improving Care After colon canceR treatment in the Netherlands
- Personalised care to Enhance quality of life -

The above mentioned developments are subject to the I CARE study. We hypothesize that general practitioner (GP) involvement improves both aftercare and preventive care resulting in improved quality of life and patients* satisfaction. Furthermore, a…

Immunogenicity of HPV-vaccination in a reduced-dose schedule

To study the kinetics of the vaccine-induced antibody response against HPV16/18 after a two-dose schedule by measuring these antibody responses at approximately 7, 12, 24, 36, 48, 60, 72, 84, 96, 108 and 120 months following the first dose of HPV-…

Phase III study comparing R-CODOX-M/R-IVAC versus dose-adjusted EPOCH-R (DA-EPOCH-R) for patients with newly diagnosed high risk Burkitt lymphoma

Primary objective:- To confirm in a multicenter setting an improvement in EFS to 95% at 2 years of DA-EPOCH-R in patients with newly diagnosed high risk Burkitt lymphoma as compared to an expected EFS of 72% at 2 years for the control arm R-CODOX-M/…

Memory response against Bordetella pertussis in adults: immunological effects of an acellular pertussis booster vaccination

The main purpose of this study is to investigate the longitudinal effects of an aP booster vaccination in adults, on long-term humoral and cellular memory immunity against B. pertussis. By measuring antibody levels against the various pertussis…

Subjective Cognitive Impairment Cohort, a focus on the earliest changes leading to Alzheimer*s disease.

The primary objective of the SCIENCe project is to establish a prospective cohort of patients with subjective complaints, to study the earliest brain changes ultimately leading to cognitive decline and dementia due to AD. Specific research questions…

Randomized phase III study comparing a non-myeloablative lymphocyte depleting regimen of chemotherapy followed by infusion of tumor infiltrating lymphocytes and interleukin-2 to standard ipilimumab treatment in metastatic melanoma

In this randomized controlled phase III study we will evaluate whether TIL infusion preceded by non-myeloablative chemotherapy and followed by high dose bolus interleukin-2 can result in an improved progression free survival when randomly compared…

Identifying subgroups with High cArdiovascular Risk in Breast cancer survivORs (HARBOR)

- to evaluate the prevalence of (sub)clinical CVD, cardiovascular risk factors and metabolic abnormalities among BC survivors treated with and without anthracyclines in two groups at (a) 5-7 years and (b) 10-12 years after diagnosis;- to…

Hsf1 Activators Lower cardiomyocyte damage: Towards a novel therapeutic approach to REVERSE atrial fibrillation.

To elucidate the correlation between proteostasis marker levels in serum and atrial tissue, and initiation and progression of AF in patients.

A Randomized, Double-Blind, Placebo-Controlled, Phase 3 Study of Nonsteroidal Aromatase Inhibitors (Anastrozole or Letrozole) Plus LY2835219, a CDK4/6 Inhibitor, or Placebo in Postmenopausal Women With Hormone Receptor-Positive, HER2-Negative Locoregionally Recurrent or Metastatic Breast Cancer With No Prior Systemic Therapy in This Disease Setting

The primary objective of Study I3Y-MC-JPBM is to compare treatment with LY2835219 plus NSAI therapy versus placebo plus NSAI therapy with respect to PFS in postmenopausal women with HR+, HER2- locoregionally recurrent or metastatic breast cancer who…

Intracranial registration in patients with refractory epilepsy, an integrative analysis of brain signals in response to sensory stimuli

To identify neuronal activation patterns in response to cognitive stimuli

ECT-induced connectivity mechanisms in treatment resistant depression

Primary objectives:1.) Investigate changes in functional connectivity between different resting state networks as a function of ECT treatment and therapeutic response.2.) Investigate changes in VTA-related BOLD-signals coding for Temporal Difference…

Evaluation of the Neurologic Assessment in Neuro-Oncology (NANO) criteria among brain cancer patients

The development of an objective, standardized and validated tool for the assessment of clinical outcome of brain tumor patients

Low dose SPIO injection for a complete magnetic, radiation-free, procedure for sentinel lymph node detection and metastases evaluation.

To investigate the possibility of using low dose peri-tumoral Magtrace® injection for a complete magnetic, radiation free, procedure for sentinel lymph node (SLN) detection and evaluation. This objective, can be sub-divided in the following…

Amyloid pathology in cognitively normal elderly subjects

This study has been transitioned to CTIS with ID 2024-518559-41-01 check the CTIS register for the current data. The main objectives are to identify markers for amyloid pathology in cognitively normal subjects, to identify risk factors for amyloid…

A phase I, multicenter, open-label study of oral ABL001 in patients with chronic myelogenous leukemia or Philadelphia Chromosome-positive acute lymphoblastic Leukemia (CABL001X2101)

Primary:Determine the MTD and/or RDE(s) of ABL001:* As a single agent for CML CP and AP patients* In combination with either nilotinib or imatinib or dasatinib in CML CP and AP patients* As a single agent for CML BP patients and Ph+ ALL…

Phase I/prospective randomized phase II trial Of the Safety and Efficacy of tamoxifen in combination with the Isoform selective Pi3K inhibitor GDC-0032 compared with tamoxifen alONe in hormone receptor positive, HER2 negative, metastatic breast cancer patients with prior exposure to endocrine treatment (POSEIDON trial)

In phase I safety and pharmacological properties of GDC-0032 in combination with tamoxifen in patients with advanced solid tumors will be investigated. The effectiveness of GDC-0032 in combination with tamoxifen will be studied in patients with…

Cancer during pregnancy: short and long term effects on mother and child.

In 2004, a multidisciplinary team of clinicians and researchers in the UZ Leuven hospital started to collaborate on the rare problem of cancer during pregnancy. The collaboration between gynaecologists, pediatricians, hematologists, farmacologists,…

A Phase 3, Randomized, Placebo-Controlled, Double-Blind Study of Oral Ixazomib Citrate (MLN9708) Maintenance Therapy in Patients With Multiple Myeloma Following Autologous Stem Cell Transplant

Study ObjectivesPrimary:• To determine the effect of ixazomib maintenance therapy on progression-free survival (PFS), compared to placebo, in patients with NDMM who have had a response (complete response [CR], very good partial response [VGPR], or…