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Nationwide prospective study on community-acquired bacterial meningitis: from genetics to therapy

The main objective of the MeninGene study is to identify genetic risk factors in host and pathogen influencing susceptibility to bacterial meningitis, and the rate of complications, unfavourable outcome and death.

A 52-Week, Phase 3, Randomized, Active Comparator and Placebo-Controlled, Parallel Design Study to Evaluate the Efficacy and Safety/Tolerability of Subcutaneous SCH 900222 / MK-3222, Followed by an Optional Long Term Safety Extension Study, in Subjects With Moderate-to-Severe Chronic Plaque Psoriasis (Protocol No. MK-3222-011)

Primary Trial ObjectivesBase Study1) Primary Efficacy Objective: To assess the efficacy of SCH 900222/MK-3222, hereafter referred to as MK-3222, compared to placebo in the treatment of moderate-to-severe chronic plaque psoriasis as measured by the…

A Phase 3, Randomized, Double-Blind Study of Nivolumab Monotherapy or Nivolumab Combined with Ipilimumab Versus Ipilimumab Monotherapy in Subjects with Previously Untreated Unresectable or Metastatic Melanoma

Primary Objectives - To compare Overall Survival (OS) and Progression free survival (PFS) of nivolumab monotherapy to ipilimumab monotherapy and that of nivolumab combined with ipilimumab to ipilimumab monotherapy in subjects with previously…

Biomarker discovery randomized phase IIb trial with carboplatin-cyclophosphamide versus paclitaxel with or without Bevacizumab as first-line treatment in advanced triple negative Breast cancer (TRIPLE-B study);Title after protocol amendment August 12, 2017:
Biomarker discovery randomized phase IIb trial with carboplatin-cyclophosphamide versus paclitaxel with or without atezolizumaB as first-line treatment in advanced triple negative Breast cancer (TRIPLE-B study)

This study has been transitioned to CTIS with ID 2024-516202-39-00 check the CTIS register for the current data. Modified objectives after implementation of protocol amendment Sept 2024: Primary: 1. Validate the BRCA1-like test* in predicting…

Zimmer Maxera acetabular system in total hip arthroplasty: a multi-center, prospective, non-controlled post marktet clinical follow-up study

The objectives of this study are to confirm the safety and performance of the Zimmer Maxera Cup mated with either a BIOLOX delta or BIOLOX OPTION femoral head when used in primary total hip arthroplasty.

A Randomized, Double-blind, Placebo-controlled Phase 3 Study of the Bruton's Tyrosine Kinase (BTK) Inhibitor, PCI-32765 (Ibrutinib), in Combination with Bendamustine and Rituximab (BR) in Subjects With Newly Diagnosed Mantle Cell Lymphoma

Primary ObjectiveThe primary objective of this study is to evaluate whether the addition of ibrutinib to bendamustine and rituximab will result in prolongation of PFS in subjects with newly diagnosed MCL who are 65 years of age or older.Secondary…

Transcranial Direct Current Stimulation to enhance treatment effects in aphasia

to investigate (1) the additional effect of tDCS on language and communication, when administered during aphasia therapy in the sub-acute phase post stroke (2) its cost-effectiveness, (3) its effect on neural reorganisation of language, and (4) the…

Utrecht Neural Prosthesis (UNP)
A pilot study on controllability of brain signals and application in locked-in patients

The main goal is to achieve a means of communication solely based on brain signals for severely paralyzed patients. Success will constitute a significant advance in the field of BCI and of severe paralysis because it will be the first system that…

Ex vivo activation characterization and targeting of the latent HIV infected reservoir to cure HIV

1. Ex vivo stimulation of HIV genome expression in latently infected peripheral blood mononuclear cells (PBMC's) from patients on cART using new and established compounds.2. To characterize latently HIV-1 infected peripheral blood mononuclear…

A Phase III, Randomised, Double Blind, Placebo Controlled, Multicentre Study of Olaparib Maintenance Monotherapy in Patients with BRCA Mutated Advanced (FIGO Stage III-IV) Ovarian Cancer following First Line Platinum Based Chemotherapy.

This study has been transitioned to CTIS with ID 2024-511142-39-00 check the CTIS register for the current data. To determine the efficacy of olaparib versus placebo on progression free survival (PFS).

A Multicenter, Randomized, Double-Blind, Placebo-Controlled, Phase III Study of ARN-509 in Men with Non-Metastatic (M0) Castration-Resistant Prostate Cancer

This study has been transitioned to CTIS with ID 2023-509221-47-00 check the CTIS register for the current data. To demonstrate superiority in the metastasis-free survival (MFS) of men with high risk NM-CRPC treated with apalutamide versus…

ASORAS Trial;AssOciation between Renal sympathetic denervation and Arterial Stiffness

The main purpose of this study is to assess the impact of arterial stiffness on the response in 24h ambulatory blood pressure reduction following renal sympathetic denervation in patients with primary hypertension with or without diastolic…

Primary Immunodeficiencies:
immunological and genetic background in relation to clinical complications

Project aims1. To provide a more precise overview of prevalence, presenting symptoms, referral routes, clinical complications and evolution during follow-up of PIDs in The Netherlands by registration and analysis of prospective patient data derived…

A RANDOMIZED TRIAL COMPARING RADICAL HYSTERECTOMY AND PELVIC
NODE DISSECTION VS SIMPLE HYSTERECTOMY AND PELVIC NODE DISSECTION
IN PATIENTS WITH LOW RISK EARLY STAGE CERVICAL CANCER

Primary objective:To evaluate whether treatment with simple hysterectomy and pelvic node dissection is non-inferior to treatment with radical hysterectomy and pelvic node dissection in terms of pelvic relapse-free survival.Secondary objectives:To…

Synovial immune alterations and biomarkers of arthritis

- to investigate different cellular, molecular, genetic and epigenetic pathogenic mechanisms in synovial tissue leading to the various inflammatory joint diseases- to investigate these changes in the synovial tissue in relationship to the duration…

A prospective evaluation of pancreatic cyst surveillance, based on the consensus statement, formulated by the European study group on cystic tumours of the pancreas

First, to establish the yield of the currently propagated pancreatic cyst surveillance program, and second, to identify possible alternative surveillance strategies, which might be more (cost) effective.

Determination of the sleep improving effects of phenolics from an orange peel extract

The present study aims to determine whether hesperidin or a hesperidin/apigenin combined preparation can improve objective sleep duration and/or sleep quality, and/or improve perceived sleep quality and feelings of rest.

The effect of a gastric bypass procedure on the pharmacokinetics of citalopram

Primary objective: to determine to what extent a gastric bypass procedure has effect on the AUC (area under the serum concentration-time curve), Cmax (maximum concentration) of citalopram.Secondary objectives:- To determine the severity of…

Dose-intensified Image-Guided Fractionated Radiosurgery for Spinal Metastases (DOSIS)

To determine whether a sustained pain relief can be achieved with dose intensified hypofractionated image guided radiosurgery in patients with vertebral metastasis and a longer life expectancy

Pharmacokinetics of micafungin (Mycamin ®) as antifungal prophylaxis given twice weekly intravenously compared to micafungin given daily to patients at risk for developing an invasive fungal disease.

The primary objective of this trial is as follows:• To determine the pharmacokinetics of micafungin 300 mg given twice weekly on Mondays and Thursdays in patients at risk for developing an invasive fungal disease (patients who are being treated for…