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Relevance of Biomarkers and Clinical Predictors of Outcome in Unselected Population with Febrile Urinary Tract Infection at Primary Care and Emergency Department in a Prospective, Randomized Cohort Trial Comparing Short (7 days) Antibiotic Treatment with Conventional Treatment (14 days)

To assess clinical parameters and biomarkers in blood and urine in predicting bacteremia, need for hospital admission, clinical and bacteriologic cure and mortality in patients with fUTI.To determine whether a 7-day duration of antibiotic treatment…

Improvement of working memory, attention and concentration after neonatal intensive care: a randomized controlled intervention study

• To evaluate short-term (directly after training) and long-term (12 months) effects of cognitive rehabilitation on (working)memory, attention, concentration, and quality of life; measured by neuropsychological assessments, and reports by parents…

Atrial Fibrillation Reduction by Renal Sympathetic Denervation

The objective of the present pilot study is to assess whether renal sympathetic denervation will decrease atrial fibrillation burden in patients with symptomatic paroxysmal of persistent atrial fibrillation

Pilot study: Role of anti-oxidants in the elicitation of contact allergic reaction to p-phenylenediamine (PPD).

Pilot study to investigate the influence of pre-treatment with an anti-oxidant solution on the elicitation reaction (the occurrence of an allergic skin reaction after contact with an allergen) in subjects with a proven sensitization to PPD.

Survey of Health, Ageing and Retirment in Europe (SHARE)

Including the collection of biological biomarkers into a social survey such as SHARE is of important scientific value as it opens up multiple research possibilities: -Identification of causal relationships: biological biomarkers can help to…

The impact of norepinephrine on top-down and bottom-up neural processing

1) To investigate the effect of atomoxetine on resting-state fMRI measures of network functional connectivity.2) To assess the effect of atomoxetine on several task performance variables, that are hypothesized to reflect tonic LC-NE activity.3) To…

The development of visual perception and social behavior in infants and toddlers

The main objective of the study is to investigate the development of and relationship between visual perception and social behavior in infants and toddlers. Secondly, the the stability of measurements in infants and toddlers will be investigated.

Moving with osteoarthritis: the effect of an altered gait pattern on knee load in persons with knee osteoarthritis

To investigate whether applying small changes to the gait pattern of patients with osteoarthritis lead to a reduction of the knee adduction moment in both the short term and long term.

Quantitative Sensory Testing in Juvenile Idiopathic Arthritis

Primary Objectives: 1.1: To evaluate the feasibility of determining sensory thresholds in patients with JIA using QST.1.2: To examine which sensory modalities are particularly affected in JIA patients compared to healthy controls in order to define…

Implementation of the Dutch national guideline * perinataal beleid bij extreme vroeggeboorte* (perinatal practice in extremely premature delivery) : the importance of Prenatal Counseling
Substudy: Needs and preferences for prenatal counseling from experienced parents

We aim to investigate the current practice of prenatal counseling amongst parents of extremely premature infants since the introduction of the new guideline in 2010. We will explore the contents and the practical aspects of the counseling.…

Plaque stabilization and restoration of vascular function by bioresorbable vascular scaffold in acute coronary syndrome prone patients

To assess if treatment of an intermediate vulnerable coronary lesion in symptomatic patients using a BVS is feasible, results in a more stable plaque, increases vessel luminal area, preserves or improves vasomotion and is not associated with…

Comparison of ABVS and HHUS
for detection and characterization of breast lesions

1. To evaluate wether ABVS could replace HHUS in women <30 year with focal breast signs2. To evaluate the performance of ABVS in comparison to HHUS in patients with high suspicion of breast cancer3. To start a pilot study to compare ABVS with…

Effect of nutritional conditioning on the pharmacokinetics of acetaminophen

To assess the effect of short term starvation and short term high fat diet on orally administered acetaminophen metabolism in healthy subjects.

A randomized, multicentre, double-blind, parallel, sham-controlled study of the gammaCore®, a non-invasive neurostimulator device for the acute relief of episodic and chronic cluster headache.

Primary Objective:The primary objective is to compare the pain free rates at 15 minutes following the use of GammaCore® with that of a sham device, for acute treatment of cluster headache attacks.Secondary Objectives:The secondary objectives will…

A Long-Term Follow-Up Study of Subjects Who Participated in a Clinical Trial in which
Peginterferon Lambda 1-a (BMS-914143) was Administered for the Treatment of Chronic Hepatitis C

Recent studies demonstrate long-term durability of virologic response with pegylated alpha-interferon-based therapies. Comparable information is not yet available for Lambda or for regimens combining lambda interferons, RBV, and DAAs. In this…

Psychosexual consequences of risk-reducing salpingo-oophorectomy in BRCA1/2 mutation carriers.

Primary objective The primary objective is to examine the effect of a MBSR intervention on the menopause-specific quality of life in BRCA1/2 mutation carriers who experience RRSO-induced menopausal complaints. Secondary objectiveThe secondary…

The effects of BCG-vaccination on the innate immune response and immunoparalysis in healthy volunteers. Two proof-of-principle studies.

In the present study, we first want to investigate whether BCG-vaccination enhances the innate immune response in humans in vivo during human endotoxemia. In the second experiment we want to investigate whether BCG-vaccination can reverse the…

Hyperinflation in COPD exacerbations

Objective: The main objective is to establish the strength of the relationship between improvements in dyspnea and health related Quality of Life (HR-QoL) with the decrease in hyperinflation during the resolution of a COPD exacerbation in the…

Biomarkers for Skin barrier and inflammation in Children with Atopic Dermatitis

To determine the relationship between phenotypic, genetic and biochemical features of AD. , Relevant bimarkers of the skin barrier function including the levels of NMFs, inflammatory mediators (e.g. IL-1 cytokines), SC lipids and serine proteases…

A phase I, randomised, double-blind, placebo-controlled study in patients with amyotrophic lateral sclerosis to further assess the safety and tolerability of intracerebroventricular administration of sNN0029 infusion solution.

The objective of the trial is to assess the safety and tolerability of i.c.v. administration of sNN0029 infusion solution at a dose of 4 µg per day delivered via a Medtronic SynchroMed® II Infusion System.