323 results
The main objective of this prospective population-based study of patients with proximal SMA in the Netherlands is to register SMA patients in the Netherlands in a socalled SMA-database to study prevalence and severity of SMA types 1-4, to perform…
To investigate the effect of cholic acid supplementation on the clinical and biochemical parameters of Zellweger spectrum disorder
1- to describe the presence and severity of hemiplegic CP on the basis of neonatal MRI findings and correlate the involvement of different structures (basal ganglia, posterior limb of the internal capsule and hemisphere) with the size of the lesion2…
The overall aim of the project is to define effects of genetic and non-genetic variants on pharmacological treatment response in children with asthma. The following questions will be answered:- What are the characteristics of children who do not…
The objective of the study is to diminish the amount of chemotherapy and/ or radiotherapy for children with Hodgkin lymphoma who are likely to receive too much treatment with current treatment protocols.
A fundamental question in the current research proposal concerns how changes in cognitive and social-emotional behavior are related to functional and anatomical brain development. The current proposal has the objective to (a) understand the neural…
To relate exposure markers of EDCs to health outcomes in children - in particular obesity and neurobehavioral disorders -, effect biomarkers, and other parameters via multiple regression and multivariate analysis, while taking into account relevant…
The primary objective of this study is to examine the effectiveness of a short, highly structured parent based speech intervention programme on speech development in VP/VLBW children with speech sound disorder (SSD) at 2 years of age.
The goal of this study is to determine whether radiosensitization with carboplatin or the addition of Isotretinoin to maintenance therapy improves cure rates for children with other than average risk medulloblastoma/PNET.
Social and emotional functioning of hearing impaired children, in the agegroup between 9 and 15 years old.
Evaluating the current dosing guidelines in children taking the half-strength paediatric tablets will provide reassurance that the recommended lopinavir/ritonavir dose provides adequate drug exposure and maintains efficacy.This trial will evaluate…
The objective of this study is to analyse the association between stress and obesity in childhood. We hypothesize that obese children have higher levels of stress than normal weight controls. The key objective is to study differences in the area un…
Primary Objectives: 1. To determine the consequences in infants and children who had a laryngotracheal reconstruction or cricotracheal resection, regardinga. quality of the voiceb. physical strain Secondary objectives:2. To determine the…
To study the effects of changing consultations by starting with the patients agenda on the enablement of children with asthma and their parents to bring forward their questions, worries, problems and beliefs.
Primary Objective: To determine the accumulation of AGEs in the skin and serum of pregnant women with DM1, DM2 or GDM, in comparison to healthy pregnant women and non-pregnant women with DM1 or DM2 and to determine the accumulation of AGEs in the…
Discover diagnostic biomarkers for disease severity. Increase the insight in the epidemiology of viral infections in the primary, secondary and tertiary care facilities and in the pathogenesis of and immunological response against viral infections.
To evaluate the blood pressure within the first year of life we will perform a prospective longitudinal study in all newborn patients with the classical form of CAH. To analyze the urinary steroid profile in CAH patients and healthy controls during…
To compare one dose of the short acting tropicamide combined with one dose of the longer acting cyclopentolate (c+t) with a double dose of the longer acting cyclopentolate (c+c). To develop a cycloplegics protocol that garantees optimal refractieve…
Research GoalsUsing cross-sectional data we will test whether control and affective brain regions follow different developmental time courses. The first study will focus on the development of inhibitory control (stimulus-driven and intentional),…
This study aims to study the following questions:1. Which differences in parent-child interaction can be identified between diagnostic groups of toddlers with clinical diagnoses?2. Which differences in parent-child interaction can be identified…