6017 results
Primary To determine the maximum tolerated dose (MTD) and characterize the dose-limiting toxicities (DLT) of LEE011 when administered orally once daily for 21 consecutive days followed by a 7 day break.Secondary *Safety and tolerability of LEE011.*…
Primary:- To test the hypothesis that the clinical effect of KJD (determined by WOMAC) is not (clinically relevant) different from TKP at 2 years post treatment (equivalence hypothesis). Secondary:- To describe and compare the clinical efficacy over…
The objective of this extension study is to find out the potential long-term benefits and safety of tolvaptan. During this study all participants will receive tolvaptan.PRIMARY OBJECTIVE is to demonstrate whether tolvaptan modifies ADPKD progression…
To assess clinical parameters and biomarkers in blood and urine in predicting bacteremia, need for hospital admission, clinical and bacteriologic cure and mortality in patients with fUTI.To determine whether a 7-day duration of antibiotic treatment…
* To study the relationship between inflammation on MRI and syndesmophyte formation with very detailedimaging methods: radiography, computed tomography (CT), 3 and 7 Tesla MRI. * To examine the time order of pathologic changes like inflammation,…
The aim of this project is to assess whether 4D-CTA can generate 3D cranial image data sets with sufficient spatial and temporal resolution to enable its use as a diagnostic tool in cerebrovascular pathology and physiology such as arteriovenous…
Part I of the study: I) to determine if one or a batch of aging marker(s) is/are associated with the presence of objectively diagnosed COPD related co-morbidity (muscle wasting, osteoporosis, cardiovascular risk, glucose intolerance, renal failure,…
1. Evaluation of gene-expression profiles of endometria of PCOS women compared to normal ovulatory women2. Identify genes and pathways which contribute to a high rate of miscarriages of PCOS women3. Identify genes and pathways related to the high…
The primary objectives of this study consist of:1. To assess the accuracy of different pulse contour methods to measure CO compared to thermodilution CO measured with a PAC in major abdominal surgery patients.2. To assess the effect of propofol…
The current study is being conducted to determine whether long-term dual-antiplatelet therapy with ticagrelor in combination with ASA (recommended daily dose 75-100 mg) is beneficial in patients with history of MI (1-3 years ago) and additional risk…
The present research protocol aims at the development and implementation of a valid self-report instrument for suicidality amongadolescents. The instrument needs to be invariant for ethnicity and needs to register fluctuations in suicide risk and…
This study is part of a prospective cohort study in the University Medical Center Groningen aimed at the determination of prognostic factors for outcome of children with TBI. The study is a pilot study to determine the value of fNIRs for detection…
Primary Objective: The painscores regarding abdominal pain among women with primary outflow obstruction in comparison with an age matched control group.Secondary Objective(s): The prevalence of sexual problems due to the congenital anomalies or the…
To investigate the feasibility and efficacy, expressed as percentage funcitoning time and time in target range, respectively, of an automated closed-loop glucose control system based on subcutaneous continuous glucose measurements in critically ill…
To validate the use of single urethral sensor catheter in demonstrating urethral pressure variations during filling cystometryIncidence of significant urethral pressure variations during urodynamic filling phase measured with three urethral sensor…
In this study, we aim to test the feasibilty, reliability and validity of the MOX-accelerometer in measuring daily physical activity in children with mitochondrial disease.
Physical functioning at the workplace in patients after total knee arthroplasty: a feasibility study
The primary aim of this pilot study is to demonstrate the feasibility of measuring physical functioning at the workplace among TKA patients and healthy colleagues objectively. Secondly, to get a first impression of objective physical functioning of…
Objective: Primary objective is to demonstrate non-inferiority of the e-prescription to the use of antidepressants on the short term. Secondary objectives are to assess its effect on long term outcomes, antidepressant use, and to assess its…
To assess the preemptive effect of Bepanthen® on decreasing the incidence of specific >= grade 2 dermatological side effects of interest in respect of compliance to EGFRI agents, HRQoL and the adherence during the 6-week skin treatment period…
The purpose of this study is to determine the need for thromboprofylaxis in patients being treated in a below-knee plaster cast after trauma of a lower extremity and if there is, to assess if both of the two tested prophylactic treatments are suited…