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An open-label, multi-center, three arm randomized, phase III study to compare the efficacy and safety of RO5072759 + chlorambucil (GClb), rituximab + chlorambucil (RClb)or chlorambucil (Clb) alone in previously untreated CLL patients with comorbidities.

The primary objective of the study is to demonstrate clinically relevant statistical superiority in progression-free survival (PFS) with GClb compared to RClb and Clb alone and RClb compared to Clb [GClb vs Clb; GClb vs RClb; RClb vs Clb] in…

A randomized, controlled, open-label, parallel-group, multi-center study to compare the effect of Intrathecal Baclofen Therapy (ITB Therapy®) versus Best Medical Treatment (BMT) on spasticity in post-stroke patients after 6 months active treatment

The objective is to determine whether ITB Therapy is more effective than oral anti-spasticity agents in reducing the spasticity.

Relevance of Biomarkers and Clinical Predictors of Outcome in Unselected Population with Febrile Urinary Tract Infection at Primary Care and Emergency Department in a Prospective, Randomized Cohort Trial Comparing Short (7 days) Antibiotic Treatment with Conventional Treatment (14 days)

To assess clinical parameters and biomarkers in blood and urine in predicting bacteremia, need for hospital admission, clinical and bacteriologic cure and mortality in patients with fUTI.To determine whether a 7-day duration of antibiotic treatment…

Augmenting response to entecavir using a temporary peginterferon alpha-2a add-on strategy for the treatment of HBeAg-positive chronic hepatitis B (ARES study)
- Long-term follow-up of a peginterferon alpha-2a add-on strategy in chronic hepatitis B patients treated with entecavir

To investigate the use of a temporary peginterferon alpha-2a add-on strategy during entecavir therapy in patients with HBeAg-positive chronic hepatitis B by comparing the efficacy of this regimen versus entecavir monotherapy.To evaluate the long-…

Reducing exacerbations in patients with chronic obstructive pulmonary disease with physiotherapy

This study aims to investigate the potential of guideline driven physiotherapy treatment as a supportive measure to postpone or prevent acute exacerbations in COPD patients. So, the primary research question is: *What is the efficacy of adding…

Prophylaxis of venous thromboembolism in patients with a fracture of the lower extremity being treated conservatively with a below-knee plaster cast.

The purpose of this study is to determine the need for thromboprofylaxis in patients being treated in a below-knee plaster cast after trauma of a lower extremity and if there is, to assess if both of the two tested prophylactic treatments are suited…

Neural mechanisms of Oxytocin in human social-emotional behaviour in males and females

To gain insight in the neurobiological mechanisms behind oxytocin effects on human social-emotional behaviour.

Vitamin D in addition to RAAS blockade and dietary sodium for the Treatment of Urinary Excretion of albumin.

The primary objective of this study is to determine the antialbuminuric response of vitamin D analogue in addition to ACE-inhibitor and low-sodium diet, in renal patients.

A double-blind, randomized, mulicenter, placebo-controlled, parallel-group study comparing the efficacy and safety of 1.25 mg FTY720 administered orally once daily versus placebo in patients with primary progressive multiple sclerosis

The purpose of this study in patients with primary progressive multiple sclerosis (PPMS) is to evaluatewhether FTY720 is effective in delaying MS disability progression in the absence of relapsescompared to placebo. Furthermore, safety and…

Non-invasive assessment of skeletal muscle involvement in Duchenne muscular dystrophy

To develop non-invasive markers for tissue changes in skeletal muscle using MR methods

Top care for children with atopic dermatitis (and asthma) within the atopy syndroom, using the digital Eczema Centre WKZ- Dutch Asthma Centre Davos

The primary research question is:Do children with atopic dermatitis and asthma after a stay in the NAD have a better coping and acceptance of their disease as compared with children treated at the outpatient department of the WKZ?Secondary research…

Pharmacologic optimization of voriconazole; a prospective cluster randomized controlled trial of therapeutic drug monitoring

The objective of this study proposal is to determine whether pharmacologic optimization of voriconazole by means of therapeutic drug monitoring (TDM) results in improved patient outcomes (efficacy and safety) and is more cost-effective compared to…

Encapsulating peritoneal sclerosis after kidney transplantation in patients previously treated by peritoneal dialysis: a prospective observational study.

Our primary objective is to determine the incidence of EPS after kidney transplantation in patients previously treated by PD. We hypothesize that there is an increasing incidence of symptomatic and asymptomatic EPS after kidney transplantation.

Immune response after Human Papillomavirus vaccination in patients with automimmune disease

Objective: The primary goal of the current study is to study the immunogenicity and safety of HPV vaccination in patients with an autoimmune disease. Based on retrospective analysis with other vaccines we hypothesize that patients with autoimmune…

Reorganisation of the sensorimotor cortex following early unilateral brain damage

1- to describe the presence and severity of hemiplegic CP on the basis of neonatal MRI findings and correlate the involvement of different structures (basal ganglia, posterior limb of the internal capsule and hemisphere) with the size of the lesion2…

**Add-on value of Bi-Atrial Pacing in combination with standardised
Sotalol treatment for the prevention of postoperative Atrial Fibrillation
after Cardiovascular Surgery."

To determine the add-on value of bi-atrial pacing in combination with standardised Sotalol treatment for the prevention of postoperative atrial fibrillation (POAF).

Pharmacogenetics of Asthma Medication in Children: Medication with Anti-inflammatory effects with special focus on Neutrophils.

The overall aim of the project is to define effects of genetic and non-genetic variants on pharmacological treatment response in children with asthma. The following questions will be answered:- What are the characteristics of children who do not…

Does paying attention to religious themes in psychotherapy influence treatment outcome?

The main aim of the study is to investigate the influence of discussing religious issues during therapy on treatment outcome, both 6 months after start of treatment and 1,5 year after start of treatment. In addition, the study will take possible…

A randomized, prospective trial of 3 weeks pre-operative hormonal treatment for hormone receptor positive breast cancer: Anastrozole, Fulvestrant or Tamoxifen Exposure - Response in molecular profile (AFTER).

To investigate prospectively how the "TAMRO-profile" performs in a pre-operative treatment setting. In addition we can examine whether the profile is specific for tamoxifen or is predictive for endocrine resistance in general. Also the…

Primary hemiarthroplasty versus conservative treatment for comminuted fractures of the proximal humerus in the elderly - A Multicenter Randomized trial

Primary objectiveTo compare the Constant scores (reflecting functional outcome and pain) at one year after primary hemiarthroplasty versus non-operative treatment in patients over 65 years of age who sustained a complex humeral fracture.Secondary…