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Weekly administration of Oral Docetaxel in combination with Ritonavir

To determine the maximum tolerated dose (MTD), dose limiting toxicities (DLT), and optimal dose of docetaxel that can safely be administered to patients with cancer in a weekly schedule. amendment 1The objective of the first amendment is to…

A phase III, randomized, controlled, single-blind, multicentre, parallel arm trial to assess the efficacy and safety of Pergoveris® (follitropin alfa and lutropin alfa) and GONAL-f® (follitropin alfa) for multifollicular development as part of an assisted reproductive technology treatment cycle in poor ovarian responders, as defined by the European Society of Human Reproduction and Embryology criteria

The primary objective of the trial is to demonstrate superiority of Pergoveris® versus GONAL-f® in poorovarian response (POR) patients defined according to modified criteria set forth by the European Society of Human Reproduction and Embryology (…

A prospective Randomized Single Blinded Clinical Study on TKA
with and without Orthosensor

The current study evaluates the OrthoSensor and investigates whether the combination of the Vanguard® Knee System with the OrthoSensor results in a faster recovery and better clinical outcomes during short follow up compared to conventional TKA (…

Atrial Fibrillation Reduction by Renal Sympathetic Denervation

The objective of the present pilot study is to assess whether renal sympathetic denervation will decrease atrial fibrillation burden in patients with symptomatic paroxysmal of persistent atrial fibrillation

Pilot study: Role of anti-oxidants in the elicitation of contact allergic reaction to p-phenylenediamine (PPD).

Pilot study to investigate the influence of pre-treatment with an anti-oxidant solution on the elicitation reaction (the occurrence of an allergic skin reaction after contact with an allergen) in subjects with a proven sensitization to PPD.

Survey of Health, Ageing and Retirment in Europe (SHARE)

Including the collection of biological biomarkers into a social survey such as SHARE is of important scientific value as it opens up multiple research possibilities: -Identification of causal relationships: biological biomarkers can help to…

The impact of norepinephrine on top-down and bottom-up neural processing

1) To investigate the effect of atomoxetine on resting-state fMRI measures of network functional connectivity.2) To assess the effect of atomoxetine on several task performance variables, that are hypothesized to reflect tonic LC-NE activity.3) To…

The effect of Staphefekt on the skin microbiome, including Staphylococcus aureus, in patients with atopic dermatitis.

To retrieve (in vivo) data about the effect of Staphefekt on the microbiome, including Staphylococcus aureus, and on disease severity in patients with atopic dermatitis.

Moving with osteoarthritis: the effect of an altered gait pattern on knee load in persons with knee osteoarthritis

To investigate whether applying small changes to the gait pattern of patients with osteoarthritis lead to a reduction of the knee adduction moment in both the short term and long term.

Proof of Concept Study of Eurartesim® in Patients with Imported Uncomplicated Plasmodium Vivax Malaria

Primary Objective:• Uncorrected Adequate Clinical and Parasitological Response (ACPR) at Day 21.Secondary Objectives: • Proportion of aparasitaemic patients (at different visits).• Proportion of afebrile patients (at different visits).• Uncorrected…

Development of an assay for detection of Circulating Endothelial Cell (CEC) and Circulating Endothelial Progenitor cell (CEP) by fluorescence-activated cell sorting (FACS) in cancer patients and healthy individuals.

Produce a reproducible method for enumeration of CECs and CEPs in peripheral blood in order to further study the usefulness of CECs and CEPs as a biomarker in LDM therapy.

Intraarticular treatment of osteoarthrits of the hip: A randomized trial of hyaluronic acid (Fermathron S) vs corticosteroids (Depomedrol).

Will the hyaluronic acid injections have impact on pain reduction and functional improvement in patients with osteoarthritis of the hip ?

Implementation of the Dutch national guideline * perinataal beleid bij extreme vroeggeboorte* (perinatal practice in extremely premature delivery) : the importance of Prenatal Counseling
Substudy: Needs and preferences for prenatal counseling from experienced parents

We aim to investigate the current practice of prenatal counseling amongst parents of extremely premature infants since the introduction of the new guideline in 2010. We will explore the contents and the practical aspects of the counseling.…

Plaque stabilization and restoration of vascular function by bioresorbable vascular scaffold in acute coronary syndrome prone patients

To assess if treatment of an intermediate vulnerable coronary lesion in symptomatic patients using a BVS is feasible, results in a more stable plaque, increases vessel luminal area, preserves or improves vasomotion and is not associated with…

Effects of timing of hypercaloric snacking diets on metabolism and brain

To determine the effects of hypercaloric HFHS snacking in the morning or evening on insulin sensitivity and serotonin function in the diencephalon.

Comparison of ABVS and HHUS
for detection and characterization of breast lesions

1. To evaluate wether ABVS could replace HHUS in women <30 year with focal breast signs2. To evaluate the performance of ABVS in comparison to HHUS in patients with high suspicion of breast cancer3. To start a pilot study to compare ABVS with…

Effect of nutritional conditioning on the pharmacokinetics of acetaminophen

To assess the effect of short term starvation and short term high fat diet on orally administered acetaminophen metabolism in healthy subjects.

A randomized, multicentre, double-blind, parallel, sham-controlled study of the gammaCore®, a non-invasive neurostimulator device for the acute relief of episodic and chronic cluster headache.

Primary Objective:The primary objective is to compare the pain free rates at 15 minutes following the use of GammaCore® with that of a sham device, for acute treatment of cluster headache attacks.Secondary Objectives:The secondary objectives will…

A Long-Term Follow-Up Study of Subjects Who Participated in a Clinical Trial in which
Peginterferon Lambda 1-a (BMS-914143) was Administered for the Treatment of Chronic Hepatitis C

Recent studies demonstrate long-term durability of virologic response with pegylated alpha-interferon-based therapies. Comparable information is not yet available for Lambda or for regimens combining lambda interferons, RBV, and DAAs. In this…

Psychosexual consequences of risk-reducing salpingo-oophorectomy in BRCA1/2 mutation carriers.

Primary objective The primary objective is to examine the effect of a MBSR intervention on the menopause-specific quality of life in BRCA1/2 mutation carriers who experience RRSO-induced menopausal complaints. Secondary objectiveThe secondary…