Search for a trial

6 months Evaluation of the BIOTRONIK CoCr PRO-Kinetic Coronary Stent System in patients with single de Novo lesions in Native Coronary Arteries

The primary objective of this study is to evaluate safety and efficacy of the BIOTRONIK PRO-Kinetic coronary CoCr-stent in patients with single de novo lesions of native coronary arteries.

Efficacy of Schema-Focused Therapy versus Usual Treatment in Forensic Patients with Personality Disorders: A Three-Year Randomized Clinical Trial

In this study, we will test the efficacy of SFT in forensic patients with 4 severe personality disorders -- Antisocial, Narcissistic, Borderline, and Paranoid Personality Disorders -- in ameliorating personality disorder symptoms and reducing risk…

Effects of bosentan on morbidity and mortality in patients with Idiopathic Pulmonary Fibrosis - a multicenter, double-blind, randomized, placebo-controlled, parallel group, event-driven, group sequential, phase III study

The objective of this trial is to demonstrate that bosentan delays disease worsening or death in patients with IPF.

A Multicenter, Open Label, Randomized Study of AMG 951 in Subjects with Previously Untreated Stage IIIb/IV Non-Small Cell Lung Cancer (NSCLC) Treated with Chemotherapy with or without Bevacizumab

Objectives:Phase 1b: To determine the maximum tolerated dose (MTD) (up to 8mg/kg/day) through safety and tolerability of multiple doses of AMG 951 administered by intravenous (IV) infusion to subjects with NSCLC in combination with chemotherapy and…

Prognostic Factors for treatment and follow-up of patients after colorectal surgery

the investigation and evaluation of certain serummarkers for inflammation and tumoractivity during the followup of colorectal neoplasms, and the applicability of these markers during the followup of these patients or the evaluation of the effect of…

The role of inactive follicle stimulating hormone in ovarian dysfunction in galactosemia.

1) To assess whether galactosemia women with ovarian failure are able to produce estradiol after exogenous (normally bioactive) FSH and LH gift 2) To characterize FSH glycan structures

Molecular pathway analysis of Amyotrophic Lateral Sclerosis by genome-wide expression profiling of human blood and skin fibroblasts.

The two objectives of our proposal are: (i) to identify specific gene expression profiles in blood and fibroblasts from patients with ALS or ALS-mimic in order to improve diagnosis and measure disease progression; (ii) the identification of genetic…

Determination of the predictive value of FDG-PET-CT scans, blood proteins and blood cells for the prognosis for patients with lung cancer receiving concurrent chemo-radiation

The objective of this study is to investigate the evolution of the 18F-deoxyglucose (FDG) uptake and the tumour characteristics determined in the plasma of patients with lung cancer during and after concurrent radiotherapy and chemotherapy.

A Phase III Randomized, Double-blind, Placebo Controlled Trial Comparing the Efficacy of Gemcitabine, Cisplatin and Sorafenib to Gemcitabine, Cisplatin and Placebo in First-Line Treatment of Patients with Stage IIIb with effusion and stage IV Non-Small Cell Lung Cancer (NSCLC)

The objective of this phase III study is to compare the efficacy of sorafenib in combination with gemcitabine and cisplatin versus placebo with gemcitabine and cisplatin for first-line treatment of patients with stage IIIB (with effusion) or Stage…

A double-blind, placebo controlled multicentre study to evaluate the efficacy and safety of MBP8298 in subjects with secondary progressive multiple sclerosis

To compare the clinical efficacy of 500 mg MBP8298 given intravenously every six months for a period of two years, to placebo, in subjects diagnosed with SPMS who are positive for the HLA DR2 and/or DR4 haplotype. Clinical efficacy is defined as a…

QUANTITATIVE IMPROVEMENTS OF HIGH RESOLUTION PET USING A HIGH RESOLUTION RESEARCH TOMOGRAPH (HRRT) IN COMPARISON WITH A CLINICAL PET CAMERA: A STUDY IN NORMAL SUBJECTS USING THE TRACERS [11C]RACLOPRIDE, [11C]FLUMAZENIL AND [11C]Verapamil.

The purpose of the study is to assess the quantitative accuracy of the experimental HRRT PET scanner and to assess the potential benefits of high resolution PET.

The effect on treatment outcome of systematic feedback on client progress and therapeutic alliance in a outpatient population.

This study investigates the effects of monitoring patient progress and the development of the therapeutic alliance from patients perspective and providing infromation to both, patients and therapists.

Long-term cardio- and neurovascular effects of radiotherapy and chemotherapy in patients with Hodgkin's lymphoma

The main objectives are :Cross-sectional:1. To investigate the extent of atherosclerotic disease of the carotid artery defined as: (a) the intima-media thickness (IMT) (b) the elasticity (c) the degree of stenosis2. To define the degree of…

Phase III trial comparing conventional adjuvant Temozolomide with dose-intensive Temozolomide in patients with newly diagnosed glioblastoma

To determine if dose-intensifying the adjuvant temozolomide component of the chemoradiation treatment enhances treatment efficacy as measured by overall survival.

The long-term immune response after HPV16 peptide vaccination in woman with low-grade pre-malignant disorders of the uterine cervix, a placebo controlled phase II study

Evaluation of the capacity of a HPV 16 peptide vaccine to install a long term HPV-specific T cell response, to define the importance of a booster vaccine after 1 year, the induction of Cytotoxic T lymphocyte (CTL) immunity against HPV16E6 and E7 and…

Bortezomib re-induction therapy combined with donor lymphocyte infusion in patients with relapsed Multiple Myeloma following allogeneic stem cell transplantation

Primary objectives:Efficacy of bortezomib combined with DLI in patients with relapse myeloma following (non) myeloablative allo-SCT as measured by- response rate including percentage of complete remission according to EBMT criteria (appendix A)-…

The effect of HPV16 peptide vaccination on the local immune response in woman with high grade HPV16+ pre-malignant disorders of the uterine cervix, a placebo controlled phase II study

This study aims to reveal whether vaccination of women with HPV 16+ cervical intraepithelial neoplasia not only results in a strong systemic T-cell response, but also endows these T-cells with the capacity to infiltrate HPV16-induced lesions.…

A Randomized, Double-Blind, Multicenter Study of Denosumab Compared with Zoledronic Acid (Zometa) in the Treatment of Bone Metastases in Men with Hormone-Refractory Prostate Cancer.

To determine if denosumab is non-inferior to zoledronic acid (Zometa) with respect to the first on-study occurrence of a skeletal-related event (SRE) in men with hormone-refractory prostate cancer and bone metastases.

Clinical Trial to Evaluate the Treatment of Atrial Fibrillation Using the
Ablation Frontiers Cardiac Ablation System

The study objective is to evaluate the safety and efficacy of the Ablation Frontiers Cardiac Ablation System in the treatment of permanent atrial fibrillation.

Skin Autofluorescence and Capillary Permeability: Relevance of Measuring Advanced Glycation Endproducts in Critically Ill Patients

Objective of this study is to provide evidence for the induction of AGEs in blood and tissue in patients with septic shock.