251 results
To investigate whether online mindfulness-based stress reduction (MBSR) therapy and an aerobe training intervention both leading to stress reduction and reduced circulatory risk in formerly preeclamptic women with increased mental stress levels…
In this study we will investigate how safe the new compound R2R01 is and how well it is tolerated when it is used by healthy participants.We also investigate how quickly and to what extent R2R01 is absorbed and eliminated from the body. In addition…
To investigate the efficacy of the acellular dermal substitute Glyaderm on wound healing in various acute complex skin and soft tissue defects.
In this study we will investigate how safe the new compound CORT113176 is and how well it is tolerated when it is used by healthy participants.We also investigate how quickly and to what extent CORT113176 is absorbed, transported, eliminated from…
Primary Objective:To evaluate recovery in patients with moderate COVID-19 after administration of SNG001 compared to placebo.Secondary Objectives:a. To evaluate the efficacy of SNG001 compared to placebo in patients with moderate COVID-19, using a…
To evaluate the effectiveness of a peer-led, video-based self-management support programme for patients with advanced cancer and their relatives. The programme aims to improve the wellbeing of patients with advanced cancer and their relatives,…
The primary objective of the study is to assess the efficacy, safety, and tolerability of ABBV 154 in comparison with placebo in subjects with moderately to severely active CD who had inadequate response to or were intolerant of prior biologics.
The aim of the follow-up study is to determine the differences between early versus late treatment with GZ / SAR402671 in the effect on total kidney volume growth (total kidney volume, TKV) and in the effect on slowing down renal impairment (change…
1.To investigate COVID-19 vaccine responses of the standard schedule of 2 vaccinations with the Moderna mRNA-1273 vaccine (primary schedule) in patients with hematologic diseases, in particular those patients who are considered immunocompromised,…
To establish baseline predictive factors for acute and late lumen growth after successful opening of chronic total occlusions. Secondary objectives are:1) Identifying the relation between change in absolute microvascular resistance and late change…
The purpose of this study is to investigate how quickly and to what extent RO6868847 is absorbed, distributed, metabolized (broken down), and eliminated from the body (this is called pharmacokinetics). A very small part of the study compound RO…
The primary objective is comparison of the CYP3A4 activity in medically castrated patients with prostate cancer with the CYP3A4 activity of male patients with other types of solid tumours. To evaluate the CYP3A4 activity, the PK of the CYP3A4…
The main objective of this project is to validate a standardized volume measurement system (using eight in-house 3D printed phantoms) to allow for reliable atrophy measurements in MS, by quantifying between-scanner and within-scanner reproducibility…
To explore, whether markers of mitochondrial dysfunction measured in isolated PBMCs or immune cell subpopulations differ between subjects with mitochondrial disorders and cardiomyopathy and healthy volunteers.
Phase 1 • Primary objective: to determine the safety and tolerability, including the attenuation phenotype of a novel late-arresting GAP, named GA2 parasite, administered by sequentially increasing numbers of mosquito bites.• Secondary objective: to…
The primary objective is to investigate the potential benefit of scheduled natural daylight exposure to improve glucose control in T2DM individuals and to unravel molecular mechanisms underlying effects of natural daylight on circadian clocks and (…
To deliver a single fraction stereotactic radiotherapy with acceptable toxicity and reduction in VT burden.
This study aims to test the hypothesis that zandelisib in combination with rituximab has better clinical activity and risk/benefit profile compared to standard 2nd line immunochemotherapy (R-CHOP/R-B) in subjects with relapsed FL or MZL. Primary…
Monitoring & evaluation of immune responses induced by COVID-19 vaccines in the general population in the Netherlands.
In this study we will investigate how quickly and to what extent PHA-022121 is absorbed, transported, and eliminated from the body (this is called pharmacokinetics). PHA-022121 will first be given as a single oral dose, and then as an infusion in a…