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Relevance of Biomarkers and Clinical Predictors of Outcome in Unselected Population with Febrile Urinary Tract Infection at Primary Care and Emergency Department in a Prospective, Randomized Cohort Trial Comparing Short (7 days) Antibiotic Treatment with Conventional Treatment (14 days)

To assess clinical parameters and biomarkers in blood and urine in predicting bacteremia, need for hospital admission, clinical and bacteriologic cure and mortality in patients with fUTI.To determine whether a 7-day duration of antibiotic treatment…

Prophylaxis of venous thromboembolism in patients with a fracture of the lower extremity being treated conservatively with a below-knee plaster cast.

The purpose of this study is to determine the need for thromboprofylaxis in patients being treated in a below-knee plaster cast after trauma of a lower extremity and if there is, to assess if both of the two tested prophylactic treatments are suited…

A double-blind, randomized, mulicenter, placebo-controlled, parallel-group study comparing the efficacy and safety of 1.25 mg FTY720 administered orally once daily versus placebo in patients with primary progressive multiple sclerosis

The purpose of this study in patients with primary progressive multiple sclerosis (PPMS) is to evaluatewhether FTY720 is effective in delaying MS disability progression in the absence of relapsescompared to placebo. Furthermore, safety and…

Reorganisation of the sensorimotor cortex following early unilateral brain damage

1- to describe the presence and severity of hemiplegic CP on the basis of neonatal MRI findings and correlate the involvement of different structures (basal ganglia, posterior limb of the internal capsule and hemisphere) with the size of the lesion2…

**Add-on value of Bi-Atrial Pacing in combination with standardised
Sotalol treatment for the prevention of postoperative Atrial Fibrillation
after Cardiovascular Surgery."

To determine the add-on value of bi-atrial pacing in combination with standardised Sotalol treatment for the prevention of postoperative atrial fibrillation (POAF).

Pharmacogenetics of Asthma Medication in Children: Medication with Anti-inflammatory effects with special focus on Neutrophils.

The overall aim of the project is to define effects of genetic and non-genetic variants on pharmacological treatment response in children with asthma. The following questions will be answered:- What are the characteristics of children who do not…

A randomized, prospective trial of 3 weeks pre-operative hormonal treatment for hormone receptor positive breast cancer: Anastrozole, Fulvestrant or Tamoxifen Exposure - Response in molecular profile (AFTER).

To investigate prospectively how the "TAMRO-profile" performs in a pre-operative treatment setting. In addition we can examine whether the profile is specific for tamoxifen or is predictive for endocrine resistance in general. Also the…

Complications of PCOS Pregnancy: Evaluating Risk

To design a multivariate prediction model of pregnancy outcome in women with PCOS with the intention to define intervention strategies for the future.

A randomized phase III study to evaluate the efficacy of chemoimmunotherapy with the monoclonal antibody Campath-1H (Alemtuzumab) given in combination with 2-weekly CHOP versus 2-weekly CHOP alone in elderly patients with previously untreated systemic peripheral T-cell lymphomas

See C4

TREATMENT ALTERNATIVES FOR SUBFERTILE WOMEN WITH CLASS II ANOVULATION NOT CONCEIVING AFTER SIX OVULATORY CYCLES WITH CLOMIPHENE CITRATE

The purpose of this study is to assess the effectiveness of extended treatment with CC compared to treatment with gonadotropins and/or the use of intra-uterine insemination (IUI), in patients who had six ovulatory cycles after CC, but did not…

Imaging in amyotrophic lateral sclerosis;
novel biomarker research with 7Tesla MRI

Identify and further explore the structural brain alterations in ALS patients in comparison to healthy controls and to investigate the correlations of anatomical changes with clinical variables.

A Randomized, Double-Blind, Placebo-Controlled, Parallel-Group, Multicenter Study to Evaluate the Efficacy, Safety, and Tolerability of Carisbamate as Adjunctive Therapy in Subjects With Partial Onset Seizures, Followed by an Open-Label Extension Study

Double-Blind Study CARISEPY3013:The primary objectives of this study are to compare the efficacy safety, and tolerability of carisbamate as adjunctive treatment of partial onset seizures, relative to placebo. The secondary objectives of this study…

Changes in body composition in patients with cancer in the upper airway and digestive tract: a prospective study

Primary aim of this study is to assess changes in body composition in patients with a carcinoma in the larynx, pharynx or oral cavity, in the period during and after treatment.Secundary aims of this study are:- to assess predictive factors for…

The effects of orally and intraduodenally administered pea protein on satiety parameters in vivo in lean and obese subjects.

In this study we will be looking at the effects of the different administration routes on release of satiety hormones by the small intestine.

A Phase IA, multicenter, open-label dose escalation study of BKM120, administered orally in adult patients with advanced solid malignancies

Primary objectiveTo determine the maximum-tolerated dose (MTD) of BKM120 as a single agent when administered orally to adult patients with advanced solid tumorsSecondary objectives* To assess the safety and tolerability of BKM120* To characterize…

Drug Eluting Balloon in Acute Myocardial Infarction

The purpose of the study is to compare the combination of DEB/BMS versus DES versus BMS alone in patients with an AMI.

Randomized, double-blind, placebo-controlled, multi-centre, multi-national study to evaluate the efficacy and safety of oral BAY 63-2521 (1 mg, 1.5 mg, 2 mg, or 2.5 mg tid) in patients with symptomatic Pulmonary Arterial Hypertension (PAH).

BAY 63 2521 is a direct stimulator of the soluble Guanylate Cyclase (sGC) and is intended for the treatment of cardiovascular diseases, especially Pulmonary Hypertension (PH).To assess the efficacy and safety of oral BAY 63 2521 in the treatment of…

Emotional intelligence in the differential diagnosis of autism spectrum disorders and personality disorders

By measuring emotional intelligence facilitate the differential diagnosis of autism spectrum disorders and personality disorders.

Curved versus Straight Stem Uncemented Total Hip Arthroplasty Osteoarthritis Multicenter trial
A prospective blinded randomised controlled multicentre trial comparing the CFP stem with straight stem total hip arthroplasties for the treatment of primary osteoarthritis of the hip.

The purpose of the study is to compare the functional result of CFP stem THA with conventional uncemented straight stem THA

Comparison of the everolimus eluting (XIENCE-V*/XIENCE-PRIME* or PROMUS* stent) with the biolimus A9 eluting NOBORI* stent in all-comers: a randomized open label study.

The main objective of the study is to investigate whether of the biolimus eluting and biodegradable polymer NOBORI* stent is non-inferior or even superior to the everolimus eluting XIENCE-V/XIENCE-PRime/PROMUS* stent in daily practice.