1429 results
Investigate the effect of having CYP2C19 and CYP2D6 genotypes at start of antidepressant therapy and it’s cost-effectiveness in the primary care setting.
We hypothesize that video consultations will be valued equivalent with F2F-visits, with a reduction in associated patient costs and total healthcare costs. In addition to that, we hypothesize that patients consider F2F-visits worth the effort and…
To establish the diagnostisch accuracy of ultrasound for the exclusion of fracture of the elbow
Primary Objective: • To investigate whether or not persistent complaints and poor outcome after mTBI be explained by an interaction between physiological and psychological factors. In other words, the aim is to investigate whether a more optimal…
Care workers and clients allocated to the intervention arm (receiving access to the ZELF program) will improve their 'stimulation behavior' and 'optimize function' respectively.
We hypothesize that CTC detection through diagnostic leukapheresis improves the detection rate among ER+, N+ primary breast cancer who have received 5 years of adjuvant endocrine therapy and will be a promising technique for risk classification in…
"The objective of this study is to evaluate the feasibility and effectiveness of a nursing nutrition intervention (Nurses for Food) on malnutrition in hospital. The intervention will be developed according to the Britisch Medical Research…
An information campaign was developed targeting early-stage KHOA patients and healthcare professionals (HCPs) to optimise timing of referral to secondary care.
The primary objective of this trial is to determine whether, in subjects with moderately to severely active UC, treating to achieve a target of corticosteroid-free symptomatic + endoscopic + histological remission is superior to a treatment target…
Objectives:(1) To determine whether the AT can be identified in individuals with slowly progressive NMD through submaximal exercise testing with respiratory gas analysis. (2) To determine the reliability of the AT assessment in individuals with…
Validation of cerebral blood flow-related biomarkers for neurodegenerative disease at an early stage
Generally, this study aims to investigate how cerebrovascular function relates to aging, mild cognitive impairment (MCI) and AD. More specifically, the aim is to identify, based on cerebrovascular function, individuals at high-risk for disease (in…
To define a link between excitatory/inhibitory (glutamate/GABA) neurotransmission and neural functioning across different brain regions (regional specificity) and to establish the relation between this link and ASD symptomatology (tapping into…
To determine the feasibility and applicability of the MRL protocol by comparing the images in upper extremity in patients with secondary lymphedema and healthy subjects, and to assess differences in the lymphatic system between the lymphedema…
Main objective:*To evaluate the dose-response relationship of 2 doses of etrasimod versus placebo as induction therapy in subjects with moderately to severely active Crohn's disease (CD).*To select an oral etrasimod dose, based on efficacy and…
The objective of this study is to demonstrate that use of the Sentinel® Cerebral Protection System significantly reduces the risk of periproceduralstroke (*72 hours) after transcatheter aortic valve replacement (TAVR).
The objective of the current study is to eveluate whether EMDR is effective in reducing PD symptoms.
The primary aim of this explorative study is to compare exercise-induced cardiac troponin elevations between athletes with different levels of coronary atherosclerosis. The secondary aim is to compare exercise responses to other cardiac biomarkers…
Primary objective: To investigate changes in biological and psychological markers for patients with an unipolar depressive disorder during treatment.. In specific, we will study the relationship between depressive symptomatology with changes in…
Primary:To compare the efficacy of abrocitinib 200 mg once daily (QD) versus dupilumab (as per label guidelines) in adult participants on background topical therapy with moderate to severe atopic dermatitis (AD).Key SecondaryTo compare the efficacy…
- To evaluate the single-dose PK and pivotal bioequivalence of 3 compounds darunavir (DRV) 675 mg, FTC 200 mg, and tenofovir alafenamide (TAF) 10 mg in the presence of cobicistat (COBI)150 mg when administered as an fixed-dose combination (FDC) (D/C…