604 results
The primary objective is to establish whether prefrontal compensatory mechanisms during working-memory performance may be enhanced by working-memory training, both in healthy older adults and MCI patients. The secondary objective is to establish age…
The main objective of this study is to detect potential biomarkers for the differentiation of PD and DLB and the differentiation of PD subtypes by using neuroimaging.
To monitor the systemic effects of radiotherapy (RT) alone or in combination with concurrent chemotherapy (CRT) (Cisplatin) on the immune response and T-cells over time in patients with HPV+ head and neck squamous cell carcinoma (HNSCC).
PrimaryTo determine whether the palatability of a newly developed formulation of valacyclovir is non-inferior to administration of crushed and suspended tablets in children, is the primary objective of the second phase of the trial.The primary…
The aim of the basic research in the laboratory is to develop new treatments to repair large bone defects, repair cartilage defects or inhibit the progression of osteoarthritis (cartilage degeneration). We focus on the following questions:1.How can…
1. To validate accelerometer cut-points to asses physical activity and sedentary behavior of breast cancer survivors. 2. To investigate the validity of accelerometers, inclinometers, heart rate and oxygen consumption to assess time spent in…
The assumptions of the traumatic effects of coercive measures as described in the literature will be examined in the present study. The research questions are how coercive measures are experienced by patients, to what extent these measures are…
The proposed study will further examine the effects of pregnancy on the human brain, by investigating structural and functional connectivity, local metabolite concentrations and neural activity related to social cognitive and memory processes.…
The primary objective of this study is to analyse the microenvironment of the primary tumour and sentinel and non-sentinel lymph node(s) (i.e. various T-cell populations, antigen presenting cells and myeloid-derived suppressor cells) in patients…
to establish primary patient derived organoid cultures from GM to study mechanisms that contribute to aggressive tumor growth and treatment resistance in primary and recurrent GM.
The aim of this study is to objectively assess 3D and functional outcomes of upper blepharoplasty on periorbital volume, dry eyes, peripheral vision, electrical activity of the frontal muscles and wellbeing in two different surgical techniques.
Objective of this study is to determine if Optical Coherence Tomography (OCT) measurements are a reliable measure of the severity of neurological impairment in patients with X-ALD and ZSD and therefore if OCT is an acceptable "surrogate"…
In this study we would like to find new biomarkers in BOS after haematopoietic stem cell transplantation (HSCT), that may lead to earlier identification of BOS than a lung function decline.
The main objective of this study is to investigate the effect of a topically applied emollient enriched with barrier lipids on the barrier properties of skin of AE patients.
Our primary objective is to investigate the effects of methylphenidate on language comprehension and creativity, and to link these effects with the effects of methylphenidate on working memory. Our secondary objective is to establish the relation…
The primary objective of this study is to analyse the microenvironment of the tumour, (sentinel) lymph nodes (i.e. various T-cell populations, antigen presenting cells and myeloid-derived suppressor cells) in patients with vulvar carcinoma. The…
Primary Objective: -To explore the percentage of positive total PEth levels in blood, as a proxy of alcohol consumption, in pregnant women during their first visit to the obstetrics department.Secondary Objectives: To explore the distribution of…
To assess whether nutritional status can affect the outcome of spatial cognition training in the brain.
With this pilot feasibility study, the feasibility of and satisfaction with an eHealth and serious gaming training based on psychological expectancy mechanisms are evaluated.
The aim of this project is to evaluate the clinical value of biomarkers in adult patients with pulmonary hypertension, in particular:1) To quantify biomarkers of neurohormonal activity as NTproBNP, endotheline-1 and of immunological activity as CRP…