1008 results
Understanding the pathophysiological mechanisms that play a role in liver cirrhosis and its complications. For that aim, we want to study the functional and morphological intestinal epithelial barrier and microbiota of both small and large intestine…
- To study the clinical characteristics and disease course of patients with LEMS with or without SCLC- To identify the characteristics of the humoral or cellular immune response that are associated with the prolonged survival of patients with SCLC…
To investigate whether sodium and potassium mutations are found in a cohort of patients with small fiber neuropathy, painful diabetic neuropathy (versus diabetes patients with no or only minor symptoms) and in patients with breast, ovarium or…
Answering the question if there are any associations between hormonal status in adolescence on the one hand, and immunological reactivity and pharmacodynamics on the other hand; and if such associations can explain the more rapid deterioration of…
Primary Objective:First we need to establish that patients with an eating disorder and healthy controls differ in mental imagery. So, the first aim of our research is to compare the nature and characteristics (emotionality, vividness and perspective…
PROUD is a multicentre prospective study, using clinical factors in combination with additional tests with the aim to clarify more about the aetiology and pathogenesis of MS.
The overall objective of this study is to examine specific cardio-metabolic and cardiovascular parameters in women of subfertile couples. This study protocol is divided in 3 studies to evaluate several cardio-metabolic/cardiovascular parameters in…
The first objective is to assess the value of colonoscopy screening in HL survivors. The second objectives are to evaluate the neoplasia characteristics and its relation to radiotherapy and chemotherapy, in order to improve the understanding of the…
In this study one of the goals is to compare 7 tesla MRI with 3 tesla MRI in terms of lesion detection in epilepsy patients and depiction of specific dysplasia-related imaging characteristics. Furthermore, resected tissue will be scanned ex-vivo at…
To compare the level of the sIL-2R between patients who are referred to the Center for Pain Medicine with a suspicion of CRPS but do not fulfill the new IASP Clinical Diagnostic Criteria for CRPS and those who do fulfill the new IASP Clinical…
PRIMARY OBJECTIVE1. To determine the contractile strength and the (ultra)structure of single diaphragm muscle fibers of mechanically ventilated patientsSECONDARY OBJECTIVE1. To determine whether diaphragm muscle fiber weakness is part of a…
The next questions will be addressed in the present study: 1. Do moderately preterm infants differ in development and attention and concentration capacities from a term and very preterm infants during the first years of life? 2. Do attention and…
To study the role of brain metabolites and macromolecules in relationship to pathogenesis, structural brain changes and clinical phenotype of ALS. This will reveal underlying molecular mechanisms of pathogenesis, structural brain changes and…
To characterize phenotypical parameters, cytokine production and epigenetic characteristics of monocytes in patients with diabetes mellitus type 2, stratified according to antidiabetic treatment regime. Ex vivo exploration of the conditions which…
Primary objective: to identify intra-individual changes of clinical and biochemical markers of AT characteristics before, and one year after bariatric surgery by:* Determining circulating AT derived biomarkers * Determining local AT biomarkers in…
To evaluate long term safety, efficacy and airway remodelling effects of BT in patients with severe asthma.
to determine if there is an alternative mechanism for urine acidification in men in response to NH4Cl other than that through ENaC
In this proof-of-concept study, we aim to characterize healthy individuals with regard to their individually predominant neural mechanism. Thereby, we aim to divide a sample of healthy individuals into three clusters based on their individual…
Here we will generate iPS cells from patients with genetic neurodevelopmental disorders and (related) healthy control individuals, that can be used to generate in vitro disease models to further study the mechanisms behind these disorders.
1. To investigate the influence of different immunosuppressive drugs on the immune response of placental derived mononuclear cells, peripheral blood derived mononuclear cells, and cord blood derived mononuclear cells.2. To investigate the neonatal…