2898 results
Understanding the pathophysiological mechanisms that play a role in liver cirrhosis and its complications. For that aim, we want to study the functional and morphological intestinal epithelial barrier and microbiota of both small and large intestine…
The objective of the study is to quantify endurance and respiratory function in subjects with MPS IV A and to better characterize the spectrum of symptoms and biochemical abnormalities in MPS IV A disease over time.
Here we propose that in order to identify causal mechanisms that explain AD/HD-related heterogeneity, an integrative approach is needed. Therefore, in this project we will study the interaction between motivation and executive function in AD/HD and…
The primary objective of this study is to investigate the effect of - short vs. long - oro-sensory exposure combined with a gastric load - low vs. high in energy -, on gastric emptying rate. As secondary outcome we want to investigate the effect of…
Morphological and functional changes of the median nerve after neurolysis for carpal tunnel syndrome
The objectives of this study are twofold:1. To describe morphological and functional changes of the median nerve after neurolysis using US and NCS. 2. To correlate the morphological and functional changes to the clinical symptoms and signs
The major research objective is to examine if acute exercise results in a more pronounced increase in acetylcarnitine concentration in sedentary subjects compared to endurance-trained subjects and if the exercise-induced increase in acetylcarnitine…
The objective of the current proposal is to further explore the pathophysiological changes that occur in patient with an IGSF1 mutation, using an established method for assessing hormone secretory characteristics.
to find evidence for frontal inhibition during planning of explicit movements just as seen in patients with conversion disorders.
In the present study the prevalence of and risk factors for vitamin D deficiency will be determined in a patient population with a fracture in the upper or lower extremity.
To investigate whether increased aldosterone levels in obese individuals lead to impairment of microvascular function through reduction of NO-availability, and to establish the role of microvasculaire dysfunction in the pathogenesis of salt-…
- To study the clinical characteristics and disease course of patients with LEMS with or without SCLC- To identify the characteristics of the humoral or cellular immune response that are associated with the prolonged survival of patients with SCLC…
The primary objective is to determine if there is an association between the presence of vertebral and/or rib anomalies and congenital malformations, aneuploidy or adverse fetal outcome, in order to assess whether detailed evaluation of the…
Primary Objective: To define a top set of genes that most reliably (r >=0.95) distinguish psoriasis from normal skin. We will define this set from differential methylation genes to indicate potential biomarkers.Secondary Objective(s):…
The overarching goal of this proposal is to investigate the environmental and genetic influences on the activity of CNS reward and satiety circuits, and to investigate whether these differences are causal to the development of obesity in humans.In…
The aim of this study is to identify risk factors for development of cardiovascular disease after TC treatment.
The aim of this protocol is threefold.1. To investigate associations between alcohol dependence with demographic data, psychiatric problems (e.g., compulsive symptoms in Obsessive Compulsive disorder, and ADHD)2. To investigate familial transmission…
The primary objectives of this study are: (1) To establish the role of brown adipose tissue in cold-induced thermogenesis before and after a cold acclimation period; (2) to study the involvement of skeletal muscle mitochondrial uncoupling in cold-…
We aim to assess gene expression patterns in cilia-producing cells from healthy controls to develop a candidate gene list for PCD.
The primary objective is to improve prediction of individual disease risk related to air pollution, by characterizing the internal and external exposome related to air pollution in Europe. The specific research questions are:1. Can novel biomarkers…
To compare the digestibility, bioavailability and subsequent muscle protein synthetic response to casein, with casein protein provided in an isolated manner versus casein in a milk matrix, in healthy elderly subjects