412 results
Here we propose that in order to identify causal mechanisms that explain AD/HD-related heterogeneity, an integrative approach is needed. Therefore, in this project we will study the interaction between motivation and executive function in AD/HD and…
The primary objective of this study is to investigate the effect of - short vs. long - oro-sensory exposure combined with a gastric load - low vs. high in energy -, on gastric emptying rate. As secondary outcome we want to investigate the effect of…
Morphological and functional changes of the median nerve after neurolysis for carpal tunnel syndrome
The objectives of this study are twofold:1. To describe morphological and functional changes of the median nerve after neurolysis using US and NCS. 2. To correlate the morphological and functional changes to the clinical symptoms and signs
The main objective of this pilot study is to determine the effects of vascular access construction on autonomic and cardiac function.
The major research objective is to examine if acute exercise results in a more pronounced increase in acetylcarnitine concentration in sedentary subjects compared to endurance-trained subjects and if the exercise-induced increase in acetylcarnitine…
The objective of the current proposal is to further explore the pathophysiological changes that occur in patient with an IGSF1 mutation, using an established method for assessing hormone secretory characteristics.
In this study, we will prospectively assess the association between serum CK and response to standard antihypertensive drugs (calcium blockers or monotherapy with other antihypertensive drugs according to the policy of the general practitioner).
to find evidence for frontal inhibition during planning of explicit movements just as seen in patients with conversion disorders.
In the present study the prevalence of and risk factors for vitamin D deficiency will be determined in a patient population with a fracture in the upper or lower extremity.
The first objective of this study is to gain insight in which neurocognitive and neurobiological processes underlie the development of externalizing behavior (in specific aggressive behavior) in the first two years of life. The second objective is…
Answering the question if there are any associations between hormonal status in adolescence on the one hand, and immunological reactivity and pharmacodynamics on the other hand; and if such associations can explain the more rapid deterioration of…
PROUD is a multicentre prospective study, using clinical factors in combination with additional tests with the aim to clarify more about the aetiology and pathogenesis of MS.
PrimaryEffective treatment regimes and preventive tools of SIB in CdLS by studying phenomenology, etiology and pathogenesis.Secondary a. Development of a flow chart for daily care (diagnostics; management) b. Evaluation whether the present study can…
The aim of our study is to measure 1) the prevalence of signs of child abuse and neglect in children with functional defecation disorders, 2) whether signs of child abuse and neglect are more common in children with functional defecation disorders…
To assess whether bile acids reach the brain after a meal
To study the effectiveness of gut-directed hypnotherapy in the treatment of IBS-like symptoms in patients with inflammatory bowel disease.
To study the frequencies and differentiation status of CD4 and CD8 T cell populations (Tnaive, TCM, TEM, TEMRA) in young (18-50) and old (>65) treatment naive metastasized melanoma patients at baseline and after treatment.
Does humoral and/or cellular rejection play a role in recurrent miscarriage of unknown etiology?Can biomarkers of humoral and/or cellular rejection be used for the detection of patients who are likely to suffer a miscarriage in a next pregnancy?
Our primary objective is to identify which intrinsic defect in Tregs is crucial for sarcoidosis pathology. To this end we will examine the genetic and functional properties of Tregs in the peripheral blood and at the site of disease, i.e. the lung…
To investigate the time course in which (peri-)implant complications (i.e. inflammation and bone loss around dental implants and implant technical complications) develop and to identify the associations of sleep bruxism with these complications.