22 results
To identify whether a short axis approach (SAA) or a long axis approach (LAA) to ultrasound guided peripheral cannulation is superior when performed by ED nurses without prior ultrasound experience.
The use of an interactive web-based Decision Aid reduces decisional conflict and increases patient satisfaction with information and care.
PENG block with phenol provides better pain relieve and mobility, and therefore quality of life, compared to current pain relieve strategies in patients with a hipfracture who are not eligible for surgery
The aim of the THRIVE study is to examine two objectives: 1. What are the mechanisms through which friendships aid resilience?a. Does friendship support relate to reduced neural stress responses in young adults with CA?b. Does friendship…
Primary objective: to register and investigate Dutch patients suspect for an inherited platelet function disorder, to assess clinical presentation, bleeding score, treatment, burden of disease and quality of life. Secondary objectives: to…
The primary objective is to investigate if the stress-induced dynamics across stress systems are impaired in patients with CT-related depression compared to non-CT-related depression and healthy controls. The secondary objective is to examine how…
Primary Objective: 1. To compare total testosterone levels between male CCH and ECH patients and healthy controls To compare total testosterone levels in males with ECH during remission (remission ECH) and during an active…
To demonstrate the ability of using non-invasive 31P-MRS to monitor changes of in vivo markers of mitochondrial function in skeletal and cardiac muscles (i.e., skeletal muscle PCr recovery rate constant and cardiac PCr/ATP ratio)…
To investigate whether high perceived stress is associated with inflammatory reprogramming of innate immune cells and their bone marrow progenitors, and with increased arterial wall inflammation, in subjects with an increased CVD risk.
In this study, we therefore aim to investigate how trained immunity is systemically regulated in kidney transplant patients and how the degree of trained immunity affects graft survival in patients. A better understanding of these processes…
Previous studies have shown that the origin of trained innate immunity lies in the bone marrow and is determined by epigenetic and metabolic reprogramming in hematopoietic stem and progenitor cells. In this study, we investigate whether long-term…
The main descriptive and analytic objectives are: Descriptive: To gather epidemiological evidence (prevalence, incidence) about the course of the mental, musculoskeletal and neurocognitive health (dependent variables) of…
Primary objectives: 1.1) To investigate to what extent the different functions of the cerebral microvasculature are impaired in type 1 diabetes; and 1.2) To investigate to what extent the different functions of the cerebral microvasculature are…
We want to remap the entire bacterial ecosystem in the gastrointestinal tract of patients with lgA nephropathy after a period of roughy two years, in order to gain insight into the processes that may play a role in the development and progression…
To identify the effect of psoriasis and the treatment with biologics on the pre-pregnancy uterine immune environment of psoriasis patients.
To assess the impact of short-term forearm immobilization on forearm muscle glucose uptake and amino acid net balance and kinetics of individuals with T2D compared with a control group with normoglycaemia.
The purpose of this protocol amendment is to meet the current and future needs of the MacTel Project’s collaborating investigators and continue meeting initial objectives. In addition, a third objective is to understand the mechanisms involved in…
Which markers and which vascular calcifications can be used as diagnostic markers in the dectecion of heart failure with preserved ejection fraction and diastolic dysfunction. Diabetes is a progressive disease. We therefore expect…
To investigate whether a reduction in social jetlag for 3 weeks can improve glycemic and metabolic control, sleep, mood and quality of life in people with (pre)diabetes.
To gain insight in the disease mechanisms of IBD, the immune system, gut and oral microbiome, environmental factors, the intestinal mucus barrier, intestinal epithelium, nutritional factors and metabolome will be studied in unaffected siblings of…