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QEEG measurements to help identify developmental disorders in children.

The main aim of this research is to search for sensitive and specific QEEG markers to differentiate between children with a developmental disorder, in this case ADHD and ASD, and a control group and to differentiate between these two developmental…

Development of non-invasive diagnostic test based on fetal DNA isolated from maternal blood (NATERA-study)

Our primary aim is to develop en perfection the diagnostic accuracy of the non-invasive tests for chromosomal aberrations in maternal blood.

BONE MINERAL DENSITY IN PROSTATE CANCER PATIENTS TREATED WITH ANDROGEN DEPRIVATION THERAPY

To assess whether a change in BMD as detected big DXA (gold standard) is comparable with the decline measured by the achilles method

Application of PET-MR- a diagnostic accuracy study of combined dwMRI and 18F-Choline PET-CT for baseline staging of prostate cancer validated by extended laparoscopic lymph node dissection.

To compare the diagnostic performance of new lymph node staging methods for prostate cancer (dwMRI fused with 18F-Choline PET-CT) with the current gold standard of staging, the extended pelvic lymph node dissection (ELND)

Mechanisms of disability in MS patients with long disease duration

*To examine the (longitudinal) association between long term clinical outcomes in MS and pathology occurring in brain grey matter, spinal cord grey matter and brain lesion load.

Stability of non-invasive human neurophysiological parameters
using transcranial magnetic stimulation

- The primary objective of this proposal is to assess the intraindividual reliability of PAS TMS, Theta-burst rTMS and ppTMS indices as measures of neural plasticity and cortical inhibition, by performing test-retest measurements separated by a…

Reported psychotic-like experiences in adolescence in general outpatient clinics and the determination of a cut-off point at the Prodromal questionnaire.

Primary Objective: The aim of this study is to determine a cut-off score at the PQ-16 with the CAARMS for better detection of adolescents 12-18 years at risk. Secondary Objective(s): To study the course of UHR in adolescents 12-18 years over a one…

Development of individual therapy for cystic fibrosis using primary epithelial tissue cultures

The overall aim of the study is to improve diagnostic and therapeutic options for people with CF, especially in the context of young children and novel CFTR-targeting drugs. Primary Objective: 1. to demonstrate relations between CFTR genotype,…

18F-FDG PET/CT versus CT imaging in staging of primary Muscle Invasive Bladder Cancer

The purpose of this prospective study is to evaluate the value of 18F-FDG PET/CT and CT for preoperative regional N staging of bladder cancer and to verify the results by comparison with histopathological analysis, the gold standard.

Optical coherence tomography in non-syndromic craniosynostosis patients

The primary objective is to obtain OCT data for children aged 4 to 10 diagnosed with non-syndromic craniosynostosis and to compare these to the normal reference values.

The occurrence of pruritis in patients with hidradenitis suppurativa:
a cross-sectional study

Primary:To determine the prevalence of pruritis in patients with hidradenitis suppurativa.Secondary:- to evaluate pruritis severity and its effect on three elements of daily activities;- to evaluate differences in extensiveness of HS in relation to…

Contrast echocardiography and vortex imaging in patients with left ventricular assist devices; single-center observational prospective study into detection of intracardiac thrombosis

The primary objective of this study is to identify in which imaging modality, including CE and vortex imaging, could help us in the early diagnoses of intracardiac thrombosis in LVAD patients. We attempt to provide a more dedicated method for the…

A phase 1 Study to Evaluate the Safety and Feasibility of Intraoperative Detection of Clear Cell Renal Cell Carcinoma Using Indium-111-DOTA-girentuximab-IRDye800CW

To assess the feasibility and safety of intraoperative dual-modality imaging in patients with renal cell carcinoma with Indium-111-DOTA-girentuximab-IRDye800CW. Secondary objectives are to assess how intraoperative fluorescence imaging results…

Improving the diagnosis and treatment of patients with head and neck squamous cell carcinoma: collection of tumor tissues ;The *HNcol* study

Objective:The aim of our study is to obtain a collection of head and neck squamous cell carcinomas that is well characterized for relevant clinical parameters, including follow-up.

Neurocognitive effects of low-grade glioma resection in eloquent areas

1) Evaluating the effect and recovery of glioma surgery in eloquent areas on cognitive functioning.2) Examining the effec tof glioma surgery in eloquent areas on quality of life.3) Examining the effect of gliomas in eloquent areas on the…

Distinguishing awareness deficits after acquired brain injury: Validation of a clinical assessment tool in a Dutch sample.

1) Main Objective: To investigate the validity, reliability and feasibility of the Clinician*s Rating Scale for evaluating impaired self-awareness and denial of disability after brain injury (CRS-ISA-DD) for use in the Dutch clinical practice.2)…

Diagnostic value of signs, symptoms and Heart-type Fatty Acid-Binding Protein (H-FABP) in evaluating patients presenting with symptoms possibly matching acute coronary syndrome in primary care

To determine the added value of signs, symptoms and H-FABP measurement in in- or excluding acute coronary syndrome in patients with thoracic complaints in general practice

Endoscopic Measurements of Mitochondrial Oxygen Tension: a dose-finding study

* To determine the minimum effective dose of 5-aminolevulinic acid (Gliolan) for adequate MitoPO2 measurements during upper endoscopy.

An intervention- based diagnostic instrument to assess parenting potential in child protection cases: improving the quality of decision making.

The proposed study will test whether the intervention-based parenting assessment of the parents* capacity to improve (VIPP-APP; Video-Feedback intervention to promote Positive Parenting for the Assessment of Parenting Potential) contributes to…

An observational study on the microcirculation in healthy children

To establish a healthy control group for microcirculatory parameters for current and future studies on the paediatric microcirculation.