72 results
The primary objective is to perform a clinical validation of the analytical method for dried blood spot microsampling of cabozantinib, pazopanib, sunitinib, Lenvatinib, nivolumab, ipilimumab, pembrolizumab, atezolizumab or bevacizumab. The secondary…
The objective of this study is to demonstrate the clinical performance of VENTANA PD-L1 (SP263) CDx Assay in terms of its ability to identify patients with metastatic NSCLC who may benefit from treatment with acasunlimab (GEN1046) in combination…
Current laboratory tests for hypersensitivity are not sensitive of do not exist for certain allergens omong which medical drugs. To objective is therefore to optimize existing in vitro tests (lymphocyte activation and proliferation test, cytokine…
The primary objective of this study is to evaluate the clinical performance of the [REDACTED] PD-L1 [REDACTED] CDx Assay in terms of its ability to identify patients with squamous metastatic NSCLC (mNSCLC) who may benefit from treatment with […
The primary objective of this feasibility study is to provide an initial assessment of OA/US imaging to distinguish between benign and malignant thyroid nodules using HbO2 and HbR as the primary biomarkers.The secondary objectives are:- To…
The primary objective is to improve the accuracy to predict glioma genotype of our previously developed algorithm *PrognosAIs* by adding advanced MRI acquired before surgery. The secondary objective is to learn the relationship between MRI signal…
The purpose of this observational pilot study is to evaluate the extent to which the combined glucose, heart rate, blood pressure, and other outcome patterns, collected from wearables, are associated with the severity of micro- and macrovascular…
The primary objective of the study is to investigate the medium to long term effects of replacing the conventional CXR exam with an ultra-low-dose CT in terms of patient health.Secondary outcomes are measures are • Quantity and type of follow-up…
The primary objective is to evaluate the supporting mechanism of the pelvic floor for a Gellhorn pessary in patients with pelvic organ prolapse immediately after insertion and one week after insertion of the Gellhorn pessary.Secondary Objectives: •…
The primary objective of this study is to evaluate the clinical performance of the [Redacted] PD-L1 [Redacted] CDx Assay in terms of its ability to identify patients with non-squamous metastatic NSCLC (mNSCLC) who may benefit from treatment with […
Measurement of intestinal oxidation-reduction potential using a smart sensing ingestible and its relation to active UC and CRC.
Primary Objective: To investigate the agreement between cuffless blood pressure monitoring values and ABPM values in patients treated for hypertension.- Expressed as a mean difference between cuffless BP monitoring values and ABPM values- The…
The primary objective of this Clinical Performance Study is to utilize the Device for performance evaluation to detect HLA-A Locus alleles as part of the eligibility criteria for patients to receive an experimental medicinal product under the DS2243…
To predict the progression of CKD with diuretic testing.
The primary aim of this study is to investigate whether a canal wall up (CWU) tympanomastoidectomy with obliteration of the mastoid and paratympanic or epitympanic spaces reduces cholesteatoma recurrence and residual rates compared to the same…
In this study, we are looking at the effectiveness of following phase 3, the maintenance phase, of the Crohn's Disease Exclusion Diet (CDED) compared to normal diet (with or without standard maintenance treatment) in children and adults with…
The primary objective is to determine whether stratified medical therapy guided by an adjunctive interventional diagnostic procedure (IDP) during the invasive management of patients with known or suspected angina but no obstructive CAD improves…
The objective of this study is to characterise and validate multidimensional latent risk and resilience mental health trajectories in a trans-syndromal sample of help-seeking young people, including identifying genetic, environmental, biological,…
The aim of this clinical study-part in the Netherlands is to identify demographic and clinical predictors of risk, diagnosis, and progression of heart failure. In the European study component, the objective is to eventually compute with this…