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Sentinel lymph node detection in patients with stage Ib-III melanoma using MultiSpectral Optoacoustic Tomotraphy (MSOT) and IndoCyanine Green (ICG)

Study the concordance rate of SLN identified using MSOT and ICG versus the standard of care with Tc99m and lymphoscintigraphic imaging.

Skin habituation after repeated suberythemal UV-exposure

To explore skin adaptation after repeated sub-erythemal UV-dose and individual factors that might underlie this process.

HEART-GP: developing a rapid rule-out strategy for acute cardiac conditions in patients with acute-onset chest pain in out-of-hours primary care

The goals of our study are: 1) to evaluate the performance of a single hs-troponin measurement using universal and sex-specific cut-off values; 2) to evaluate whether embedding hs-troponin in a clinical risk score (HEART, INTERCHEST, Marburg Heart…

DEBBIE-ASL Pilot

Implement BBB-ASL at VUmc and assess the reliability and reproducibility of f measurements in healthy volunteers and patients with glioma

Understanding and objectively measuring paratonia in persons with dementia: a surface electromyography approach

Because experimental evidence suggested the possibility to measure paratonia through muscle activity, the primary aim of this study is to develop an objective non-invasive tool based on surface electromyography (sEMG) to quantify the presence and…

Arginine-stimulated indication of early outcome after islet transplantation

Primary Objective: We aim to create a prediction model to predict islet graft function at 3 months post-transplantation, using early islet graft function assessed in the first week after islet transplantation.Secondary Objective(s): - To determine…

Liquid biopsy in mamma carcinoma

- special attention for the development and harmonization of the pre-analysis of liquid biopsy, for blood as well as urine, andnext to this for ctDNA- special attention for the detection of PIK3CA mutations in blood and urineSimultaneously also the…

Minimal invasive Microwave Ablation in early stage breaST cancER, a feasibility study

To assess whether minimally invasive nonsurgical microwave ablation (MWA) followed by postprocedural MRI scan can be an alternative treatment for breast surgery in early stage breast cancer: a non-inferiority study .Is the quality of life, cosmetic…

Prediction of Sepsis in the Emergency Room with Pulse Wave applied Machine Learning

The primary aim of this study is early identification of sepsis (and septic shock) and cardiovascular instability, based on the hemodynamic profile of ED patients. Continuous noninvasive arterial pressure waveform signals will be collected with the…

Non-invasive preimplantation genetic testing (niPGT) - haplotyping by sequencing embryo spent culture medium

1. Develop non-invasive PGT based on cfDNA in SCM (i.e. waste material) of IVF embryos generated for PGT-M and PGT-SR.2. Develop non-invasive PGT for aneuploidy origin (niPGT-AO) to assess the rate of aneuploidies and the origin and assess the…

Improving the understanding of the anatomy and lymph flow in the central lymphatic system in patients with Noonan Syndrome Spectrum Disorder

To get a better insight into the central conducting lymphatic system in adult volunteers with Noonan Syndrome (NS) without clinical symptoms or signs of lymphatic disease compared to NS and CardioFacioCutaan syndrome patients with severe lymphatic…

Clinical validation of novel point-of-care hs-cTn assay in identifying patients with myocardial infarction

Primary objective: To define the optimal cut-off concentrations for the POC hs-cTnI assay to rule out or rule in MI.Secondary objective: To determine and validate an assay-specific 0/1-h algorithm for ruling out and ruling in MI.

A pilot study to test the PCOS risk algorithm (PriskA)

In this study we aim to assess the validity of the PriskA algorithm to diagnose PCOS in a pilot study with patients presenting with signs and symptoms of PCOS. The study also aims to collect information on the user experience from the clinicians and…

MRHeatflow-Study: an observational study of changes in pelvic circulation during radiotherapy with or without hyperthermia in patients with cancer of the small pelvis

Investigation of pelvic blood circulation by MRI in women with a gynaecological cancer who will have curative radiotherapy with or without weekly HT for inoperable pelvic tumours.

Implementation of prehospital high Sensitive troponin and risk Stratification- validation phase

validation Phase objective: Primary objective is to validate the high sensitive Troponin Quidel Triage True hsTnI. Secondary objective is to determine the applicability and repeatability. The focus will be on the ease of use, time spent performing…

Use of [15O] H2O PET to determine lower extremity muscle perfusion in patients with peripheral artery disease

The primary aim of this study is to correlate regional muscle perfusion measured with [15O] H2O PET in patients with advanced PAD to local skin perfusion measured with TcPO2. Secondary objectives are to compare pre-revascularization perfusion rates…

Validation of an Intestinal Ultrasound Score Evaluating Inflammation and Treatment Response in Crohn*s Disease (USE-IT): A Prospective Multicenter Study.

Primary Objective:The primary objective of this study is to prospectively validate a novel intestinal ultrasound (IUS) Crohn*s disease (CD) activity index and component items, correlating CD activity and responsiveness to therapy as evaluated by IUS…

Assessment of coronary stent patency by photon counting CT

To assess the diagnostic performance of PCCT to identify the luminal patency compared with ICA as the reference standard, in patients with a history of PCI with stent placement and to assess image quality by applying different image reconstruction…

Validation of a Short MRI Surveillance (SMS) protocol for hepatocellular
carcinoma screening in practice.

To evaluate our proposed SMS protocol in high-risk patients and compare it to a bi-annual US screening.

Autobiographical memory in refugees with PTSD: a multiple baseline study on the effects of the Memory Specificity Training (MEST) and a sleep protocol (SLEE-P) as a preparation for Narrative Exposure Therapy (NET)

The primary objectives of the current study are 1) to investigate the effect of the MEST and SLEE-P on targeting overgeneral autobiographical memory, sleep disturbance, and posttraumatic stress symptoms in refugees with PTSD, and 2) to explore…