108 results
We hypothesize that verapamil reduces progression from paroxysmal to persistent AF, improves rate control, exercise tolerance and quality of life and reduces costs compared to metoprolol.
2.1 Primary objectives2.1.1 Cross-sectional part• Technical evaluation of the functional and structural outcome measures to support a biomarker qualification by regulatory authorities and payers. 2.1.2 Longitudinal part • Assessment of prognostic…
Primary Objective: To determine the safety and tolerability of NF135.C10 sporozoite immunization under chemoprophylaxisSecondary Objectives:• To determine the dose-dependent protective efficacy of NF135.C10 CPS-immunization against homologous…
By providing patients reliable information and daily checklists via an app, we aim to give the patient a tool to be involved in the management of the catheter use. In this way, inappropriate use should be better signaled and discouraged, and the…
We hypothesize (based on literature) that the incidence of chronic pain in The Netherlands is around 15-20% in patients presenting to the emergency department with (acute) pain related complaints. We have no further hypothesis, because of the…
The aim of this Eat well, Move well intervention is to study the effect (in addition to DOW) on physical performance, nutritional status, delaying or preventing institutionalization, number of falls, and quality of life of frail older adults with…
The aim of the study is to document the presence and/or post-operative development of PVD and to assess its influence on the incidence of PRD in myopic patients in a time period of three and five years after lens surgery.
The primary objective is to identify joint trajectories of mobility and perceived fatigue from hospital admission to 6 months post-discharge in acutely admitted hospitalized older patients. Secondary objectives are:(1) to explore associations of…
The objective of the study is to evaluate the (cost-)effectiveness of a stepped-care approach starting with HypoAware, compared with CGM in type 1 diabetes patients with an impaired awareness of hypoglycemia.
To assess the effects of intradialytic exercise and protein ingestion on amino acid loss into the dialysate and plasma total amino acid concentrations.
To get insights into how the composition of the meal can affect the effects of prolonged sitting and sitting interrupted with physical activity on cognitive function and other health outcomes.
The objective of this study is to statistically identify the optimal level of contact-pressure for DBT. *Optimal* is defined as a weighed sum of three clinical interests: as high as possible lesion conspicuity, as low as possible absorbed glandular…
To assess the safety and reactogenicity of HB-101.To assess the immunogenicity of HB-101.
Study the long term effects of frequent exposure to high sound levels on hearing status in orchestral musicians. To assess the hearing condition, several clinically available tests will be used, but for the assessment of diplacusis a new test is…
Our main goal is to establish whether there is difference in the effect between the use of aspirin, dualtherapy aspirin/clopidogrel, or ticagrelor on the occurrence of atherothrombotic events in patients following lower extremity peripheral…
Is additional protein delivery directly after mobilization effective in delaying muscle atrophy (measured by muscle thickness determined with ultrasonography) in subjects with critical illness compared to early mobilization and continuous protein…
Primary Objective: To compare the composition and functionality of neonatal microbiome arising from mothers receiving antibiotic prophylaxis before skin incision with the microbiome of neonates born when antibiotics are given after umbilical cord…
In the present study we aim to assess the efficacy of a 14-days intervention with monomeric and oligomeric flavanols from Vitis vinifera seeds and Pinus pinaster bark (MOF-VVPB) which are the active principle in Masquelier*s® French Pine Bark…
The aim of this study is to find a directly applicable intervention for acutely suicidal patients, so that the risk of these patients committing suicide is substantially lowered, leading to fewer actual suicides. To this end we propose a randomized…
The purpose of the overall project is to adapt an existing self management tool for adults to the needs of young people and how to implement the adapted app within the youth mental health. The overall project consists of three different phases with…