Search for a trial

The effect of (chemo- or bio)radiation on functional capacity, fatigue and quality of life in patients with head and neck cancer: a trial within cohorts, the VITAL study.

Primary Objective: - To determine and compare physical performance in patients with HNC with and without an exercise intervention.Secondary Objective(s): - To determine and compare muscle strength in patients with HNC with and without an exercise…

Digital, blended lifestyle intervention program for remission and improved management of type 2 diabetes

Primary Objective: 1. To determine the effectiveness of a personalised, holistic 24-week digital lifestyle programme in achieving diabetes type 2 (T2DM) remission independence from blood glucose-lowering medications, in a Dutch population, in…

Mid-term follow-up of a randomized controlled trial comparing ultrasound-guided double percutaneous needling versus high-energy extracorporeal shockwave therapy in the treatment of calcific tendinitis of the rotator cuff.

The objective of this study is to analyse the longterm effectiveness of high-energy ESWT and ultrasound-guided needling in patients with symptomatic calcific tendinitis of the rotator cuff. The assessment parameters are the functional outcome, pain…

An international prospective umbrella trial for children with atypical teratoid/rhabdoid tumours (ATRT)
including
A randomized phase III study evaluating the non-inferiority of three courses of high-dose chemotherapy (HDCT) compared to focal radiotherapy as consolidation therapy

This study has been transitioned to CTIS with ID 2022-501456-28-00 check the CTIS register for the current data. Primary objectives Part A:To test the non-inferiority, as evaluated by OS, of three courses of HDCT compared to focal RT plus…

Comparison of two mandibular advancement devices in mild to moderate obstructive sleep apnea (OSA) patients: a randomized crossover trial

To our best knowledge, there are no studies on the preference of OSA patients for one or another MAD type based on its design characteristics. Therefore, the main objective of the study is to compare these MADs on the aspect of preference of…

The COllaborative Neonatal NEtwork for the first CPAM Trial, the CONNECT

The main objective is to identify the optimal management for patients with an asymptomatic CPAM, based on functional outcome measures. Furthermore, the primary objective is to stratify asymptomatic CPAM patients into a low and high risk group for…

An open-label, 8-week, proof of concept trial on thymosin-α1 (thymalfasin) in the treatment of primary antibody deficiency (PAD) associated mood disorders (TIDAM).

Based on the effects of Tα1 on immune cell function, the known disturbances in T lymphocyte numbers and subsets in patients with CVID and the increased prevalence of mood disorders in these patients the following research questions have been…

A Proof-of-Concept Study to Explore the Potential Efficacy of Deferiprone in Patients With
Pelizaeus-Merzbacher disease (PMD)

This study has been transitioned to CTIS with ID 2024-511968-81-00 check the CTIS register for the current data. Studying the effect of deferiprone on the motor function of patients with Pelizaeus-Merzbacher disease.

Pulmonary vein isolation or atrioventricular node ablation in patients with heart failure and symptomatic atrial fibrillation diminishing CRT response (PULVERISE-AF-CRT): A randomized study

Primary objective: to study in patients with heart failure and AF whether PVI or atrioventricular node ablation is non inferior with regard to all-cause mortality, cardiovascular hospitalization or changes in quality of life. Secondary objective: to…

Liver transplantation in patients with CirrHosis and severe Acute-on-Chronic Liver Failure (ACLF): iNdications and outComEs (CHANCE)

1. Primary objective: Survival results of LT in patients with severe ACLF To compare 1-year graft and patient survival rates after LT in patients with ACLF-2 or 3 at the time of LT with patients with decompensated cirrhosis without ACLF 2-3 and…

The impact of a preoperative very low calorie ketogenic diet (VLCKD) on body composition in patients undergoing bariatric surgery: an open trial

The main objective of the proposed study is to investigate the effect of a VLCKD on body composition in patients undergoing bariatric surgery, and to compare this with a standard VLCD.

Virtual reality as a treatment for alcohol use disorder

The main goal of the study is to examine if cue-exposure therapy through virtual reality (VR CET) can contribute to decreasing subjective craving in patients who suffer from alcohol use disorder (AUD). Further, the questions will be addressed…

Routine Outcome Monitoring for Geriatric Psychiatry & Science 2.0

The primary aim of the Routine Outcome Monitoring for Geriatric Psychiatry & Science 2.0 project (ROM-GPS 2.0) is 1) to evaluate treatment outcome for affective disorders in specialised geriatric mental health care and 2) to examine the…

International cooperative prospective study for children and adolescents with standard risk ALK-positive anaplastic large cell lymphoma (ALCL) estimating the efficacy of Vinblastine.

This study has been transitioned to CTIS with ID 2022-501454-11-00 check the CTIS register for the current data. PRIMARY OBJECTIVE:- To show that it is possible to cure at least 75% of patients belonging to the SR group with Vinblastine-monotherapy…

A Randomised Double-Blind Placebo-Controlled Phase III Clinical
Study to Evaluate the Efficacy and Safety of Cobitolimod as an
Induction and Maintenance Therapy in Participants with Moderate
to Severe Active Left-Sided Ulcerative Colitis

Study Objectives:Primary Objective: InductionTo evaluate the efficacy of cobitolimod treatment compared to placebo in inducing clinical remission, in participants with moderate to severe active left-sided UC.Secondary Objectives: Induction• To…

Optical Coherence Tomography (OCT) guided Percutaneous Transluminal Angiography (PTA) in lesions below the knee: a proof of concept study

This proof-of-concept study aims to prove the safety and usability of OCT in BTK lesions. Furthermore, it aims to provide information on the discrepancy between objective measurement of the vessel diameter using OCT versus the estimated vessel…

Comparing the migration and inducible displacement through RSA of the cementless ATTUNETM Rotating Platform and the cementless LCS Rotating Platform Knee system; A Clinical Randomized Controlled RSA follow-up study*

The primary aim of this study is to accurately compare the mid and long-term migration of two uncemented total knee prostheses. The secondary objectives of this study are to evaluate whether inducible displacement can be used as a parameter to…

The use of direct nerve visualisation with the Evotouch/7starscope compared to the conventional fluoroscopy technique for transforaminal epidural injection.

We hypothesize that using the Evotouch/7stascope, ultrasound guided TFEI procedures are non-inferior to the golden standard with fluoroscopy, which means correct placement of the needle within the neuroforamen without intravascular positioning.

Shoulder instability Trial comparing Arthroscopic stabilization Benefits compared with Latarjet procedure Evaluation (STABLE)

Prior to large trial, we will conduct a pilot trial comparing compare arthroscopic capsuloligamentous repair vs. coracoid transfer (Latarjet procedure) on recurrent dislocation rates and functional outcomes over a 24-month period.Primary questionsWe…

EPIPAIN trial: Radiofrequency therapy at 448 kHz for persisting pain after episiotomy - a feasibility study

To evaluate the feasibility of MCRRF therapy in women with persisting perineal pain after episiotomy. Collection of pilot data is essential in the preparation of a larger randomized-controlled trial that investigates the efficacy of MCRRF therapy.