1103 results
Investigate the effect of having CYP2C19 and CYP2D6 genotypes at start of antidepressant therapy and it’s cost-effectiveness in the primary care setting.
To establish the diagnostisch accuracy of ultrasound for the exclusion of fracture of the elbow
We hypothesize that CTC detection through diagnostic leukapheresis improves the detection rate among ER+, N+ primary breast cancer who have received 5 years of adjuvant endocrine therapy and will be a promising technique for risk classification in…
the application of EMDR therapy is associated with a significant decrease in severity of depressive symptoms and decrease of percentage of patients meeting DSM-5 criteria for MDD compared to the waiting list. Participants receiving EMDR report after…
The primary objective of this trial is to determine whether, in subjects with moderately to severely active UC, treating to achieve a target of corticosteroid-free symptomatic + endoscopic + histological remission is superior to a treatment target…
Objectives:(1) To determine whether the AT can be identified in individuals with slowly progressive NMD through submaximal exercise testing with respiratory gas analysis. (2) To determine the reliability of the AT assessment in individuals with…
Validation of cerebral blood flow-related biomarkers for neurodegenerative disease at an early stage
Generally, this study aims to investigate how cerebrovascular function relates to aging, mild cognitive impairment (MCI) and AD. More specifically, the aim is to identify, based on cerebrovascular function, individuals at high-risk for disease (in…
To determine the feasibility and applicability of the MRL protocol by comparing the images in upper extremity in patients with secondary lymphedema and healthy subjects, and to assess differences in the lymphatic system between the lymphedema…
Main objective:*To evaluate the dose-response relationship of 2 doses of etrasimod versus placebo as induction therapy in subjects with moderately to severely active Crohn's disease (CD).*To select an oral etrasimod dose, based on efficacy and…
The objective of the current study is to eveluate whether EMDR is effective in reducing PD symptoms.
Primary:To compare the efficacy of abrocitinib 200 mg once daily (QD) versus dupilumab (as per label guidelines) in adult participants on background topical therapy with moderate to severe atopic dermatitis (AD).Key SecondaryTo compare the efficacy…
- To evaluate the single-dose PK and pivotal bioequivalence of 3 compounds darunavir (DRV) 675 mg, FTC 200 mg, and tenofovir alafenamide (TAF) 10 mg in the presence of cobicistat (COBI)150 mg when administered as an fixed-dose combination (FDC) (D/C…
Primary: To investigate if CVL-865 decreases subjective anxiety symptoms elicited by a 35% CO2 inhalation challenge.Secondary: To investigate if CVL-865 decreases subjective fear symptoms elicited by a 35% CO2 inhalation challenge. To investigate if…
The comparison of standard fat grafting with enriched fat grafting.
Evaluation of the feasibility of a trial on the efficacy of oral esketamine for the treatment of depression and/or demoralization in patients with advanced cancer who receive palliative care.
To evaluate and quantify the various clinical effects of closed-loop SCS versus open-loop SCS on the underlying pathophysiological effects in CRPS.
The primary objective of this project is to investigate whether using prognostic factors from the PD, NP and PP domain will lead to a better prediction of treatment outcome in veterans with PTSD. Our secondary objective is to investigate whether the…
Primary Objectives: To evaluate the status of the circadian rhythm of critically ill children in multiple facets and on multiple moments during their PICU stay. To describe the distributions of rhythmic parameters in the paediatric ICU and their…
- special attention for the development and harmonization of the pre-analysis of liquid biopsy, for blood as well as urine, and next to this for ctDNA as well as ctRNA- special attention for the detection of AR-V7 in blood and urine- special…
The current research is focused on finding a method that is able to better stratify the patients. A possible method could be to study PSA in more detail, specifically the modifications which are present on the protein. One of these modifications is…